RT Journal Article SR 00 ID 10.1016/j.expneurol.2010.01.013 A1 Tonnesen, Jan A1 Gonzalez Seiz, Emma A1 Ramos Gomez, Milagros A1 Lindval, Olle A1 Martinez Serrano, Alberto A1 Kokaia, Merab T1 Functional properties of the human ventral mesencephalic neural stem cell line hVM1. JF Experimental Neurology YR 2010 FD 2010-06 VO 223 IS 2 SP 653 OP 653 K1 Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease AB The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions PB Elsevier SN 0014-4886 LK https://oa.upm.es/8596/ UL http://www.sciencedirect.com/science/journal/00144886