RT Journal Article
SR 00
ID 10.1016/j.expneurol.2010.01.013
A1 Tonnesen, Jan
A1 Gonzalez Seiz, Emma
A1 Ramos Gomez, Milagros
A1 Lindval, Olle
A1 Martinez Serrano, Alberto
A1 Kokaia, Merab
T1 Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
JF Experimental Neurology
YR 2010
FD 2010-06
VO 223
IS 2
SP 653
OP 653
K1 Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease
AB The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions
PB Elsevier
SN 0014-4886
LK http://oa.upm.es/8596/
UL http://www.sciencedirect.com/science/journal/00144886