%V 223
%P 653-653
%L upm8596
%D 2010
%R 10.1016/j.expneurol.2010.01.013
%K Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease
%T Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
%I Elsevier
%A Jan Tonnesen
%A Emma Gonzalez Seiz
%A Milagros Ramos Gomez
%A Olle Lindval
%A Alberto Martinez Serrano
%A Merab Kokaia
%J Experimental Neurology
%X The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions
%N 2