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Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment
Cita
Chen, Mengwei, Wu, Jiaojiao, Ning, Peng, Wang, Jingjing, Ma, Zuan, Huang, Liqun, Plaza Baonza, Gustavo Ramón 
ORCID: https://orcid.org/0000-0002-5555-5498, Shen, Yajing, Xu, Chang, Han, Yu, Lesniak, Maciej S., Liu, Zhongmin and Cheng, Yu
(2020).
Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment.
"Small", v. 16
(n. 3);
p. 1905424.
ISSN 1613-6829.
https://doi.org/10.1002/smll.201905424.
ORCID: https://orcid.org/0000-0002-5555-5498, Shen, Yajing, Xu, Chang, Han, Yu, Lesniak, Maciej S., Liu, Zhongmin and Cheng, Yu
(2020).
Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment.
"Small", v. 16
(n. 3);
p. 1905424.
ISSN 1613-6829.
https://doi.org/10.1002/smll.201905424.
Descripción
| Título: | Remote Control of Mechanical Forces via Mitochondrial-Targeted Magnetic Nanospinners for Efficient Cancer Treatment |
|---|---|
| Autor/es: |
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| Tipo de Documento: | Artículo |
| Título de Revista/Publicación: | Small |
| Fecha: | 23 Enero 2020 |
| ISSN: | 1613-6829 |
| Volumen: | 16 |
| Número: | 3 |
| Materias: | |
| Palabras Clave Informales: | Apoptosis; Cancer; magnetic nanocubes; magnetomechanical destruction; Anisotropy; Apoptosis; Cancer; Cell; Cell Line, Tumor; Cell Lineage; Delivery; Design; DESTRUCTION; Humans; magnetic nanocubes; Magnetics; magnetomechanical destruction; Manipulation; Mechanical Phenomena; Mitochondria; Mitochondrial; Nanoparticles; Nanotechnology; Neoplasms; Surface |
| Escuela: | E.T.S.I. Caminos, Canales y Puertos (UPM) |
| Departamento: | Ciencia de los Materiales |
| Licencias Creative Commons: | Ninguna |
Resumen
In cells, mechanical forces play a key role in impacting cell behaviors, including adhesion, differentiation, migration, and death. Herein, a 20 nm mitochondria-targeted zinc-doped iron oxide nanocube is designed as a nanospinner to exert mechanical forces under a rotating magnetic field (RMF) at 15 Hz and 40 mT to fight against cancer. The nanospinners can efficiently target the mitochondria of cancer cells. By means of the RMF, the nanocubes assemble in alignment with the external field and produce a localized mechanical force to impair the cancer cells. Both in vitro and in vivo studies show that the nanospinners can damage the cancer cells and reduce the brain tumor growth rate after the application of the RMF. This nanoplatform provides an effective magnetomechanical approach to treat deep-seated tumors in a spatiotemporal fashion.© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Más información
| ID de Registro: | 86831 |
|---|---|
| Identificador DC: | https://oa.upm.es/86831/ |
| Identificador OAI: | oai:oa.upm.es:86831 |
| URL Portal Científico: | https://portalcientifico.upm.es/es/ipublic/item/6016088 |
| Identificador DOI: | 10.1002/smll.201905424 |
| URL Oficial: | https://onlinelibrary.wiley.com/doi/10.1002/smll.2... |
| Depositado por: | iMarina Portal Científico |
| Depositado el: | 24 Ene 2025 07:53 |
| Ultima Modificación: | 24 Ene 2025 07:53 |
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