Mechanical behaviour and rupture of normal and pathological human ascending aortic wall

García Herrera, Claudio Moisés; Atienza Riera, José Miguel; Rojo Pérez, Francisco Javier; Claes, Els; Guinea Tortuero, Gustavo V.; Celentano, Diego J.; García Montero, M. y Burgos, R.L. (2012). Mechanical behaviour and rupture of normal and pathological human ascending aortic wall. "Medical and Biological Engineering and Computing", v. 50 (n. 6); pp. 559-566. ISSN 0140-0118. https://doi.org/10.1007/s11517-012-0876-x.

Descripción

Título: Mechanical behaviour and rupture of normal and pathological human ascending aortic wall
Autor/es:
  • García Herrera, Claudio Moisés
  • Atienza Riera, José Miguel
  • Rojo Pérez, Francisco Javier
  • Claes, Els
  • Guinea Tortuero, Gustavo V.
  • Celentano, Diego J.
  • García Montero, M.
  • Burgos, R.L.
Tipo de Documento: Artículo
Título de Revista/Publicación: Medical and Biological Engineering and Computing
Fecha: Junio 2012
Volumen: 50
Materias:
Escuela: E.T.S.I. Caminos, Canales y Puertos (UPM)
Departamento: Ciencia de los Materiales
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The mechanical properties of aortic wall, both healthy and pathological, are needed in order to develop and improve diagnostic and interventional criteria, and for the development of mechanical models to assess arterial integrity. This study focuses on the mechanical behaviour and rupture conditions of the human ascending aorta and its relationship with age and pathologies. Fresh ascending aortic specimens harvested from 23 healthy donors, 12 patients with bicuspid aortic valve (BAV) and 14 with aneurysm were tensile-tested in vitro under physiological conditions. Tensile strength, stretch at failure and elbow stress were measured. The obtained results showed that age causes a major reduction in the mechanical parameters of healthy ascending aortic tissue, and that no significant differences are found between the mechanical strength of aneurysmal or BAV aortic specimens and the corresponding age-matched control group. The physiological level of the stress in the circumferential direction was also computed to assess the physiological operation range of healthy and diseased ascending aortas. The mean physiological wall stress acting on pathologic aortas was found to be far from rupture, with factors of safety (defined as the ratio of tensile strength to the mean wall stress) larger than six. In contrast, the physiological operation of pathologic vessels lays in the stiff part of the response curve, losing part of its function of damping the pressure waves from the heart.

Más información

ID de Registro: 12125
Identificador DC: http://oa.upm.es/12125/
Identificador OAI: oai:oa.upm.es:12125
Identificador DOI: 10.1007/s11517-012-0876-x
URL Oficial: http://www.springerlink.com/content/u206t713x7322510/
Depositado por: Memoria Investigacion
Depositado el: 12 Sep 2012 09:02
Ultima Modificación: 21 Abr 2016 11:18
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