Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis

Pradana Pérez, Juan Angel and Durand Alegría, Jesús Senén and Fernández Hernando, Pilar and Narros Sierra, Adolfo (2011). Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis. "Luminiscence", v. 27 (n. 1); pp. 44-49. ISSN 1522-7243. https://doi.org/10.1002/bio.1323.

Description

Title: Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis
Author/s:
  • Pradana Pérez, Juan Angel
  • Durand Alegría, Jesús Senén
  • Fernández Hernando, Pilar
  • Narros Sierra, Adolfo
Item Type: Article
Título de Revista/Publicación: Luminiscence
Date: June 2011
ISSN: 1522-7243
Volume: 27
Subjects:
Freetext Keywords: quinolinic hydrazide;vanadium(IV);dipyrone;chemiluminescence;FIA
Faculty: E.T.S.I. Industriales (UPM)
Department: Ingeniería Química Industrial y del Medio Ambiente
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations. The method is based on the chemiluminescent reaction between quinolinic hydrazide and hydrogen peroxide in a strongly alkaline medium, in which vanadium(IV) acts as a catalyst. Principal chemical and physical variables involved in the flow-injection system were optimized using a modified simplex method. The variations in the quantum yield observed when dipyrone was present in the reaction medium were used to determine the concentration of this compound. The proposed method requires no preconcentration steps and reliably quantifies dipyrone over the linear range 1–50 µg/mL. In addition, a sample throughput of 85 samples/h is possible. Copyright © 2011 John Wiley & Sons, Ltd.

More information

Item ID: 12275
DC Identifier: http://oa.upm.es/12275/
OAI Identifier: oai:oa.upm.es:12275
DOI: 10.1002/bio.1323
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/bio.1323/abstract
Deposited by: Memoria Investigacion
Deposited on: 30 Aug 2012 11:58
Last Modified: 21 Apr 2016 11:31
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