Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis

Pradana Pérez, Juan Angel; Durand Alegría, Jesús Senén; Fernández Hernando, Pilar y Narros Sierra, Adolfo (2011). Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis. "Luminiscence", v. 27 (n. 1); pp. 44-49. ISSN 1522-7243. https://doi.org/10.1002/bio.1323.

Descripción

Título: Determination of Dipyrone in pharmaceutical preparations based on the chemiluminescent reaction of the quinolinic hydrazide-H2O2-vanadium (IV) system and flow injection analysis
Autor/es:
  • Pradana Pérez, Juan Angel
  • Durand Alegría, Jesús Senén
  • Fernández Hernando, Pilar
  • Narros Sierra, Adolfo
Tipo de Documento: Artículo
Título de Revista/Publicación: Luminiscence
Fecha: Junio 2011
Volumen: 27
Materias:
Palabras Clave Informales: quinolinic hydrazide;vanadium(IV);dipyrone;chemiluminescence;FIA
Escuela: E.T.S.I. Industriales (UPM)
Departamento: Ingeniería Química Industrial y del Medio Ambiente
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

A rapid, economic and sensitive chemiluminescent method involving flow-injection analysis was developed for the determination of dipyrone in pharmaceutical preparations. The method is based on the chemiluminescent reaction between quinolinic hydrazide and hydrogen peroxide in a strongly alkaline medium, in which vanadium(IV) acts as a catalyst. Principal chemical and physical variables involved in the flow-injection system were optimized using a modified simplex method. The variations in the quantum yield observed when dipyrone was present in the reaction medium were used to determine the concentration of this compound. The proposed method requires no preconcentration steps and reliably quantifies dipyrone over the linear range 1–50 µg/mL. In addition, a sample throughput of 85 samples/h is possible. Copyright © 2011 John Wiley & Sons, Ltd.

Más información

ID de Registro: 12275
Identificador DC: http://oa.upm.es/12275/
Identificador OAI: oai:oa.upm.es:12275
Identificador DOI: 10.1002/bio.1323
URL Oficial: http://onlinelibrary.wiley.com/doi/10.1002/bio.1323/abstract
Depositado por: Memoria Investigacion
Depositado el: 30 Ago 2012 11:58
Ultima Modificación: 21 Abr 2016 11:31
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