Assembling models of embryo development: Image analysis and the construction of digital atlases

Castro González, Carlos and Ledesma Carbayo, María Jesús and Peyrieras, Nadine and Santos Lleo, Andres de (2012). Assembling models of embryo development: Image analysis and the construction of digital atlases. "Birth Defects Research Part C", v. 96 (n. 2); pp. 109-120. ISSN 1542-9768. https://doi.org/10.1002/bdrc.21012.

Description

Title: Assembling models of embryo development: Image analysis and the construction of digital atlases
Author/s:
  • Castro González, Carlos
  • Ledesma Carbayo, María Jesús
  • Peyrieras, Nadine
  • Santos Lleo, Andres de
Item Type: Article
Título de Revista/Publicación: Birth Defects Research Part C
Date: June 2012
ISSN: 1542-9768
Volume: 96
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Ingeniería Electrónica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview

Abstract

Digital atlases of animal development provide a quantitative description of morphogenesis, opening the path toward processes modeling. Prototypic atlases offer a data integration framework where to gather information from cohorts of individuals with phenotypic variability. Relevant information for further theoretical reconstruction includes measurements in time and space for cell behaviors and gene expression. The latter as well as data integration in a prototypic model, rely on image processing strategies. Developing the tools to integrate and analyze biological multidimensional data are highly relevant for assessing chemical toxicity or performing drugs preclinical testing. This article surveys some of the most prominent efforts to assemble these prototypes, categorizes them according to salient criteria and discusses the key questions in the field and the future challenges toward the reconstruction of multiscale dynamics in model organisms.

More information

Item ID: 15215
DC Identifier: http://oa.upm.es/15215/
OAI Identifier: oai:oa.upm.es:15215
DOI: 10.1002/bdrc.21012
Official URL: http://onlinelibrary.wiley.com/doi/10.1002/bdrc.21012/full
Deposited by: Memoria Investigacion
Deposited on: 10 Jun 2013 19:23
Last Modified: 17 Jan 2017 12:23
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM