Dysfunctional and compensatory duality in mild cognitive impairment during a continuous recognition memory task

Bajo Breton, Ricardo (2012). Dysfunctional and compensatory duality in mild cognitive impairment during a continuous recognition memory task. "International Journal of Psychophysiology", v. 87 (n. 1); pp. 95-102. ISSN 0167-8760. https://doi.org/10.1016/j.ijpsycho.2012.11.008.

Description

Title: Dysfunctional and compensatory duality in mild cognitive impairment during a continuous recognition memory task
Author/s:
  • Bajo Breton, Ricardo
Item Type: Article
Título de Revista/Publicación: International Journal of Psychophysiology
Date: 2012
ISSN: 0167-8760
Volume: 87
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

One of the current issues of debate in the study of mild cognitive impairment (MCI) is deviations of oscillatory brain responses from normal brain states and its dynamics. This work aims to characterize the differences of power in brain oscillations during the execution of a recognition memory task in MCI subjects in comparison with elderly controls. Magnetoencephalographic (MEG) signals were recorded during a continuous recognition memory task performance. Oscillatory brain activity during the recognition phase of the task was analyzed by wavelet transform in the source space by means of minimum norm algorithm. Both groups obtained a 77% hit ratio. In comparison with healthy controls, MCI subjects showed increased theta (p < 0.001), lower beta reduction (p < 0.001) and decreased alpha and gamma power (p < 0.002 and p < 0.001 respectively) in frontal, temporal and parietal areas during early and late latencies. Our results point towards a dual pattern of activity (increase and decrease) which is indicative of MCI and specific to certain time windows, frequency bands and brain regions. These results could represent two neurophysiological sides of MCI. Characterizing these opposing processes may contribute to the understanding of the disorder.

More information

Item ID: 15262
DC Identifier: http://oa.upm.es/15262/
OAI Identifier: oai:oa.upm.es:15262
DOI: 10.1016/j.ijpsycho.2012.11.008
Official URL: http://www.sciencedirect.com/science/article/pii/S016787601200668X
Deposited by: Memoria Investigacion
Deposited on: 20 Sep 2013 18:23
Last Modified: 21 Apr 2016 15:18
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