Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

Palacín Gómez, Aranzazu; Gomez Casado, Cristina; Rivas, Luis; Aguirre, Jacobo; Tordesillas Villuendas, Leticia; Bartra, Joan; Blanco, Carlos; Carrillo, Teresa; Cuesta-Herranz, Javier; Frutos, Consolación de; García Álvarez-Eire, Genoveva; Fernández, Francisco; Gamboa, P.M.; Muñoz, Rosa; Sánchez-Monge Laguna de Rins, Rosa; Sirvent, Sofía; Torres, María; Varela Losada, Susana; Rodríguez, Rosalía; Parro, Victor; Blanca, Miguel; Salcedo Duran, Gabriel y Díaz Perales, Araceli (2012). Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.. "Plos One", v. 7 (n. 12 e50); pp. 1-10. ISSN 1932-6203. https://doi.org/10.1371/journal.pone.0050799.

Descripción

Título: Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.
Autor/es:
  • Palacín Gómez, Aranzazu
  • Gomez Casado, Cristina
  • Rivas, Luis
  • Aguirre, Jacobo
  • Tordesillas Villuendas, Leticia
  • Bartra, Joan
  • Blanco, Carlos
  • Carrillo, Teresa
  • Cuesta-Herranz, Javier
  • Frutos, Consolación de
  • García Álvarez-Eire, Genoveva
  • Fernández, Francisco
  • Gamboa, P.M.
  • Muñoz, Rosa
  • Sánchez-Monge Laguna de Rins, Rosa
  • Sirvent, Sofía
  • Torres, María
  • Varela Losada, Susana
  • Rodríguez, Rosalía
  • Parro, Victor
  • Blanca, Miguel
  • Salcedo Duran, Gabriel
  • Díaz Perales, Araceli
Tipo de Documento: Artículo
Título de Revista/Publicación: Plos One
Fecha: Diciembre 2012
Volumen: 7
Materias:
Escuela: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Departamento: Biotecnologia [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

The study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.

Más información

ID de Registro: 16187
Identificador DC: http://oa.upm.es/16187/
Identificador OAI: oai:oa.upm.es:16187
Identificador DOI: 10.1371/journal.pone.0050799
URL Oficial: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0050799
Depositado por: Memoria Investigacion
Depositado el: 05 Jul 2013 13:30
Ultima Modificación: 21 Abr 2016 16:30
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