Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies

Alonso Calvo, Raul; Pérez del Rey, David; Bucur, Anca; Van Leeuwen, Jasper; Claerhout, Brecht y De Schepper, Kristof (2012). Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies. En: "Proceedings of a meeting held 11-13 November 2012", 11/11/2012 - 13/11/2012, Larnaca, Cyprus. ISBN 978-1-4673-4357-2. pp. 413-421.

Descripción

Título: Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies
Autor/es:
  • Alonso Calvo, Raul
  • Pérez del Rey, David
  • Bucur, Anca
  • Van Leeuwen, Jasper
  • Claerhout, Brecht
  • De Schepper, Kristof
Tipo de Documento: Ponencia en Congreso o Jornada (Artículo)
Título del Evento: Proceedings of a meeting held 11-13 November 2012
Fechas del Evento: 11/11/2012 - 13/11/2012
Lugar del Evento: Larnaca, Cyprus
Título del Libro: Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on
Fecha: 2012
ISBN: 978-1-4673-4357-2
Materias:
Palabras Clave Informales: clinical trials, eligibility criteria, oncology, concepts, medical ontologies, SNOMED-CT, MedDRA, LOINC, ensayos clínicos, criterios de admisión, oncología, conceptos, ontologías médicas.
Escuela: Facultad de Informática (UPM) [antigua denominación]
Departamento: Lenguajes y Sistemas Informáticos e Ingeniería del Software
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

An important objective of the INTEGRATE project1 is to build tools that support the efficient execution of post-genomic multi-centric clinical trials in breast cancer, which includes the automatic assessment of the eligibility of patients for available trials. The population suited to be enrolled in a trial is described by a set of free-text eligibility criteria that are both syntactically and semantically complex. At the same time, the assessment of the eligibility of a patient for a trial requires the (machineprocessable) understanding of the semantics of the eligibility criteria in order to further evaluate if the patient data available for example in the hospital EHR satisfies these criteria. This paper presents an analysis of the semantics of the clinical trial eligibility criteria based on relevant medical ontologies in the clinical research domain: SNOMED-CT, LOINC, MedDRA. We detect subsets of these widely-adopted ontologies that characterize the semantics of the eligibility criteria of trials in various clinical domains and compare these sets. Next, we evaluate the occurrence frequency of the concepts in the concrete case of breast cancer (which is our first application domain) in order to provide meaningful priorities for the task of binding/mapping these ontology concepts to the actual patient data. We further assess the effort required to extend our approach to new domains in terms of additional semantic mappings that need to be developed.

Más información

ID de Registro: 19500
Identificador DC: http://oa.upm.es/19500/
Identificador OAI: oai:oa.upm.es:19500
URL Oficial: http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6399762&tag=1
Depositado por: Memoria Investigacion
Depositado el: 04 Oct 2013 17:24
Ultima Modificación: 14 Mar 2016 13:51
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