Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies

Alonso Calvo, Raul and Pérez del Rey, David and Bucur, Anca and Van Leeuwen, Jasper and Claerhout, Brecht and De Schepper, Kristof (2012). Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies. In: "Proceedings of a meeting held 11-13 November 2012", 11/11/2012 - 13/11/2012, Larnaca, Cyprus. ISBN 978-1-4673-4357-2. pp. 413-421.

Description

Title: Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies
Author/s:
  • Alonso Calvo, Raul
  • Pérez del Rey, David
  • Bucur, Anca
  • Van Leeuwen, Jasper
  • Claerhout, Brecht
  • De Schepper, Kristof
Item Type: Presentation at Congress or Conference (Article)
Event Title: Proceedings of a meeting held 11-13 November 2012
Event Dates: 11/11/2012 - 13/11/2012
Event Location: Larnaca, Cyprus
Title of Book: Bioinformatics & Bioengineering (BIBE), 2012 IEEE 12th International Conference on
Date: 2012
ISBN: 978-1-4673-4357-2
Subjects:
Freetext Keywords: clinical trials, eligibility criteria, oncology, concepts, medical ontologies, SNOMED-CT, MedDRA, LOINC, ensayos clínicos, criterios de admisión, oncología, conceptos, ontologías médicas.
Faculty: Facultad de Informática (UPM)
Department: Lenguajes y Sistemas Informáticos e Ingeniería del Software
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

An important objective of the INTEGRATE project1 is to build tools that support the efficient execution of post-genomic multi-centric clinical trials in breast cancer, which includes the automatic assessment of the eligibility of patients for available trials. The population suited to be enrolled in a trial is described by a set of free-text eligibility criteria that are both syntactically and semantically complex. At the same time, the assessment of the eligibility of a patient for a trial requires the (machineprocessable) understanding of the semantics of the eligibility criteria in order to further evaluate if the patient data available for example in the hospital EHR satisfies these criteria. This paper presents an analysis of the semantics of the clinical trial eligibility criteria based on relevant medical ontologies in the clinical research domain: SNOMED-CT, LOINC, MedDRA. We detect subsets of these widely-adopted ontologies that characterize the semantics of the eligibility criteria of trials in various clinical domains and compare these sets. Next, we evaluate the occurrence frequency of the concepts in the concrete case of breast cancer (which is our first application domain) in order to provide meaningful priorities for the task of binding/mapping these ontology concepts to the actual patient data. We further assess the effort required to extend our approach to new domains in terms of additional semantic mappings that need to be developed.

More information

Item ID: 19500
DC Identifier: http://oa.upm.es/19500/
OAI Identifier: oai:oa.upm.es:19500
Official URL: http://ieeexplore.ieee.org/xpls/abs_all.jsp?arnumber=6399762&tag=1
Deposited by: Memoria Investigacion
Deposited on: 04 Oct 2013 17:24
Last Modified: 14 Mar 2016 13:51
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