Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

Martinez de Lagran, M. and Benavides-Piccione, Ruth and Ballesteros-Yañez, Inmaculada and Calvo, M. and Morales, M. and Fillat, C. and Felipe Oroquieta, Javier de and Ramakers, G.J.A. and Dierssen, M. (2012). Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons. "Cerebral Cortex", v. 22 (n. 12); pp. 2867-2877. ISSN 1047-3211. https://doi.org/10.1093/cercor/bhr362.

Description

Title: Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons
Author/s:
  • Martinez de Lagran, M.
  • Benavides-Piccione, Ruth
  • Ballesteros-Yañez, Inmaculada
  • Calvo, M.
  • Morales, M.
  • Fillat, C.
  • Felipe Oroquieta, Javier de
  • Ramakers, G.J.A.
  • Dierssen, M.
Item Type: Article
Título de Revista/Publicación: Cerebral Cortex
Date: December 2012
ISSN: 1047-3211
Volume: 22
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (3MB) | Preview

Abstract

Down syndrome (DS) is the most frequent genetic cause of mental retardation. Cognitive dysfunction in these patients is correlated with reduced dendritic branching and complexity, along with fewer spines of abnormal shape that characterize the cortical neuronal profile of DS. DS phenotypes are caused by the disruptive effect of specific trisomic genes. Here, we report that overexpression of dual-specificity tyrosine phosphorylation-regulated kinase 1A, DYRK1A, is sufficient to produce the dendritic alterations observed in DS patients. Engineered changes in Dyrk1A gene dosage in vivo strongly alter the postnatal dendritic arborization processes with a similar progression than in humans. In cultured mammalian cortical neurons, we determined a reduction of neurite outgrowth and synaptogenesis. The mechanism underlying neurite dysgenesia involves changes in the dynamic reorganization of the cytoskeleton.

More information

Item ID: 19827
DC Identifier: http://oa.upm.es/19827/
OAI Identifier: oai:oa.upm.es:19827
DOI: 10.1093/cercor/bhr362
Official URL: http://cercor.oxfordjournals.org/content/22/12/2867.abstract
Deposited by: Memoria Investigacion
Deposited on: 16 Oct 2013 18:15
Last Modified: 21 Apr 2016 21:24
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM