Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms

Morales, Juan and Benavides-Piccione, Ruth and Rodriguez, Angel and Pastor, Luis and Yuste, Rafael and Felipe Oroquieta, Javier de (2012). Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms. "Neuroinformatics", v. 10 (n. 4); pp. 391-407. ISSN 1539-2791. https://doi.org/10.1007/s12021-012-9153-2.

Description

Title: Three-Dimensional Analysis of Spiny Dendrites Using Straightening and Unrolling Transforms
Author/s:
  • Morales, Juan
  • Benavides-Piccione, Ruth
  • Rodriguez, Angel
  • Pastor, Luis
  • Yuste, Rafael
  • Felipe Oroquieta, Javier de
Item Type: Article
Título de Revista/Publicación: Neuroinformatics
Date: October 2012
ISSN: 1539-2791
Volume: 10
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Current understanding of the synaptic organization of the brain depends to a large extent on knowledge about the synaptic inputs to the neurons. Indeed, the dendritic surfaces of pyramidal cells (the most common neuron in the cerebral cortex) are covered by thin protrusions named dendritic spines. These represent the targets of most excitatory synapses in the cerebral cortex and therefore, dendritic spines prove critical in learning, memory and cognition. This paper presents a new method that facilitates the analysis of the 3D structure of spine insertions in dendrites, providing insight on spine distribution patterns. This method is based both on the implementation of straightening and unrolling transformations to move the analysis process to a planar, unfolded arrangement, and on the design of DISPINE, an interactive environment that supports the visual analysis of 3D patterns.

More information

Item ID: 20183
DC Identifier: http://oa.upm.es/20183/
OAI Identifier: oai:oa.upm.es:20183
DOI: 10.1007/s12021-012-9153-2
Official URL: http://link.springer.com/article/10.1007%2Fs12021-012-9153-2
Deposited by: Memoria Investigacion
Deposited on: 16 Oct 2013 17:29
Last Modified: 21 Apr 2016 22:41
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