Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience

Strange, Bryan A.; Gartmann, N.; Brenninkmeyer, Jessica; Haaker, Jan; Reif, Andreas; Kalisch, Raffael y Büchel, Christian (2014). Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience. "NeuroImage", v. 84 ; pp. 922-931. ISSN 1053-8119. https://doi.org/10.1016/j.neuroimage.2013.09.065.

Descripción

Título: Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience
Autor/es:
  • Strange, Bryan A.
  • Gartmann, N.
  • Brenninkmeyer, Jessica
  • Haaker, Jan
  • Reif, Andreas
  • Kalisch, Raffael
  • Büchel, Christian
Tipo de Documento: Artículo
Título de Revista/Publicación: NeuroImage
Fecha: Febrero 2014
Volumen: 84
Materias:
Palabras Clave Informales: Dopamine; DRD4 promoter polymorphism; Memory; Novelty; Hippocampus; fMRI
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Tecnología Fotónica [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Animal models and human functional imaging data implicate the dopamine system in mediating enhanced encoding of novel stimuli into human memory. A separate line of investigation suggests an association between a functional polymorphism in the promoter region for the human dopamine 4 receptor gene (DRD4) and sensitivity to novelty. We demonstrate, in two independent samples, that the -521Cmayor queT DRD4 promoter polymorphism determines the magnitude of human memory enhancement for contextually novel, perceptual oddball stimuli in an allele dose-dependent manner. The genotype-dependent memory enhancement conferred by the C allele is associated with increased neuronal responses during successful encoding of perceptual oddballs in the ventral striatum, an effect which is again allele dose-dependent. Furthermore, with repeated presentations of oddball stimuli, this memory advantage decreases, an effect mirrored by adaptation of activation in the hippocampus and substantia nigra/ventral tegmental area in C carriers only. Thus, a dynamic modulation of human memory enhancement for perceptually salient stimuli is associated with activation of a dopaminergic-hippocampal system, which is critically dependent on a functional polymorphism in the DRD4 promoter region.

Más información

ID de Registro: 26430
Identificador DC: http://oa.upm.es/26430/
Identificador OAI: oai:oa.upm.es:26430
Identificador DOI: 10.1016/j.neuroimage.2013.09.065
URL Oficial: http://www.sciencedirect.com/science/article/pii/S105381191301001X
Depositado por: Memoria Investigacion
Depositado el: 01 Jun 2014 07:52
Ultima Modificación: 01 Feb 2015 23:56
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