Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience

Strange, Bryan A. and Gartmann, N. and Brenninkmeyer, Jessica and Haaker, Jan and Reif, Andreas and Kalisch, Raffael and Büchel, Christian (2014). Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience. "NeuroImage", v. 84 ; pp. 922-931. ISSN 1053-8119. https://doi.org/10.1016/j.neuroimage.2013.09.065.

Description

Title: Dopamine receptor 4 promoter polymorphism modulates memory and neuronal responses to salience
Author/s:
  • Strange, Bryan A.
  • Gartmann, N.
  • Brenninkmeyer, Jessica
  • Haaker, Jan
  • Reif, Andreas
  • Kalisch, Raffael
  • Büchel, Christian
Item Type: Article
Título de Revista/Publicación: NeuroImage
Date: February 2014
ISSN: 1053-8119
Volume: 84
Subjects:
Freetext Keywords: Dopamine; DRD4 promoter polymorphism; Memory; Novelty; Hippocampus; fMRI
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Animal models and human functional imaging data implicate the dopamine system in mediating enhanced encoding of novel stimuli into human memory. A separate line of investigation suggests an association between a functional polymorphism in the promoter region for the human dopamine 4 receptor gene (DRD4) and sensitivity to novelty. We demonstrate, in two independent samples, that the -521Cmayor queT DRD4 promoter polymorphism determines the magnitude of human memory enhancement for contextually novel, perceptual oddball stimuli in an allele dose-dependent manner. The genotype-dependent memory enhancement conferred by the C allele is associated with increased neuronal responses during successful encoding of perceptual oddballs in the ventral striatum, an effect which is again allele dose-dependent. Furthermore, with repeated presentations of oddball stimuli, this memory advantage decreases, an effect mirrored by adaptation of activation in the hippocampus and substantia nigra/ventral tegmental area in C carriers only. Thus, a dynamic modulation of human memory enhancement for perceptually salient stimuli is associated with activation of a dopaminergic-hippocampal system, which is critically dependent on a functional polymorphism in the DRD4 promoter region.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainSAF2011-27766UnspecifiedUnspecifiedUnspecified
FP7304248EMOTIONCOGUnspecifiedExploring the Effects of Emotion on Human Cognition

More information

Item ID: 26430
DC Identifier: http://oa.upm.es/26430/
OAI Identifier: oai:oa.upm.es:26430
DOI: 10.1016/j.neuroimage.2013.09.065
Official URL: http://www.sciencedirect.com/science/article/pii/S105381191301001X
Deposited by: Memoria Investigacion
Deposited on: 01 Jun 2014 07:52
Last Modified: 11 Apr 2019 09:56
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