Functional hubs in mild cognitive impairment

Navas Santo-Tomas, Adrian; Papo, David; Boccaletti, Stefano; Pozo Guerrero, Francisco del; Bajo Breton, Ricardo; Maestú, Fernando; Gil, Pablo; Sendiña Nadal, Irene y Buldú, J.M. (2015). Functional hubs in mild cognitive impairment. "International Journal of Bifurcation and Chaos", v. 25 (n. 3); pp. 1-10. ISSN 0218-1274. https://doi.org/10.1142/S0218127415500340.

Descripción

Título: Functional hubs in mild cognitive impairment
Autor/es:
  • Navas Santo-Tomas, Adrian
  • Papo, David
  • Boccaletti, Stefano
  • Pozo Guerrero, Francisco del
  • Bajo Breton, Ricardo
  • Maestú, Fernando
  • Gil, Pablo
  • Sendiña Nadal, Irene
  • Buldú, J.M.
Tipo de Documento: Artículo
Título de Revista/Publicación: International Journal of Bifurcation and Chaos
Fecha: Marzo 2015
Volumen: 25
Materias:
Palabras Clave Informales: Functional brain networks, synchronization likelihood, centrality, hub characterization, mild cognitive impairment
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Otro
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

We investigate how hubs of functional brain networks are modified as a result of mild cognitive impairment (MCI), a condition causing a slight but noticeable decline in cognitive abilities, which sometimes precedes the onset of Alzheimer's disease. We used magnetoencephalography (MEG) to investigate the functional brain networks of a group of patients suffering from MCI and a control group of healthy subjects, during the execution of a short-term memory task. Couplings between brain sites were evaluated using synchronization likelihood, from which a network of functional interdependencies was constructed and the centrality, i.e. importance, of their nodes was quantified. The results showed that, with respect to healthy controls, MCI patients were associated with decreases and increases in hub centrality respectively in occipital and central scalp regions, supporting the hypothesis that MCI modifies functional brain network topology, leading to more random structures.

Más información

ID de Registro: 26570
Identificador DC: http://oa.upm.es/26570/
Identificador OAI: oai:oa.upm.es:26570
Identificador DOI: 10.1142/S0218127415500340
URL Oficial: http://www.worldscientific.com/doi/abs/10.1142/S0218127415500340
Depositado por: Memoria Investigacion
Depositado el: 13 Abr 2015 16:46
Ultima Modificación: 01 Abr 2016 22:56
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