DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data

Ortuño Fisac, Juan Enrique; Ledesma Carbayo, María Jesús; Simões, Rui V.; Candiota, Ana Paula; Arús, Carles y Santos Lleo, Andres de (2013). DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data. "BMC Bioinformatics", v. 14 ; pp. 1-17. ISSN 1471-2105. https://doi.org/10.1186/1471-2105-14-316.

Descripción

Título: DCE@urLAB: a dynamic contrast-enhanced MRI pharmacokinetic analysis tool for preclinical data
Autor/es:
  • Ortuño Fisac, Juan Enrique
  • Ledesma Carbayo, María Jesús
  • Simões, Rui V.
  • Candiota, Ana Paula
  • Arús, Carles
  • Santos Lleo, Andres de
Tipo de Documento: Artículo
Título de Revista/Publicación: BMC Bioinformatics
Fecha: 2013
Volumen: 14
Materias:
Palabras Clave Informales: DCE-MRI; Imaging; Levenberg-Marquardt; Fitting; Preclinical; Pharmacokinetics; Animal models; High field MR; IDL
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Ingeniería Electrónica
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Background DCE@urLAB is a software application for analysis of dynamic contrast-enhanced magnetic resonance imaging data (DCE-MRI). The tool incorporates a friendly graphical user interface (GUI) to interactively select and analyze a region of interest (ROI) within the image set, taking into account the tissue concentration of the contrast agent (CA) and its effect on pixel intensity. Results Pixel-wise model-based quantitative parameters are estimated by fitting DCE-MRI data to several pharmacokinetic models using the Levenberg-Marquardt algorithm (LMA). DCE@urLAB also includes the semi-quantitative parametric and heuristic analysis approaches commonly used in practice. This software application has been programmed in the Interactive Data Language (IDL) and tested both with publicly available simulated data and preclinical studies from tumor-bearing mouse brains. Conclusions A user-friendly solution for applying pharmacokinetic and non-quantitative analysis DCE-MRI in preclinical studies has been implemented and tested. The proposed tool has been specially designed for easy selection of multi-pixel ROIs. A public release of DCE@urLAB, together with the open source code and sample datasets, is available at http://www.die.upm.es/im/archives/DCEurLAB/ webcite.

Más información

ID de Registro: 28901
Identificador DC: http://oa.upm.es/28901/
Identificador OAI: oai:oa.upm.es:28901
Identificador DOI: 10.1186/1471-2105-14-316
URL Oficial: http://www.biomedcentral.com/1471-2105/14/316
Depositado por: Memoria Investigacion
Depositado el: 07 Jun 2014 12:39
Ultima Modificación: 22 Sep 2014 11:43
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