Cognitive reserve is associated with the functional organization of brain networks in healthy aging: a MEG study

López García, María Eugenia and Aurtenetxe, Sara and Pereda, Ernesto and Cuesta Prieto, Pablo and Perales Castellanos, Nazareth and Bruña Fernandez, Ricardo and Niso Galán, Julia Guiomar and Maestu Unturbe, Fernando and Bajo Breton, Ricardo (2014). Cognitive reserve is associated with the functional organization of brain networks in healthy aging: a MEG study. "Frontiers in Aging Neuroscience", v. 6 (n. 125); pp. 1-9. ISSN 1663-4365. https://doi.org/10.3389/fnagi.2014.00125.

Description

Title: Cognitive reserve is associated with the functional organization of brain networks in healthy aging: a MEG study
Author/s:
  • López García, María Eugenia
  • Aurtenetxe, Sara
  • Pereda, Ernesto
  • Cuesta Prieto, Pablo
  • Perales Castellanos, Nazareth
  • Bruña Fernandez, Ricardo
  • Niso Galán, Julia Guiomar
  • Maestu Unturbe, Fernando
  • Bajo Breton, Ricardo
Item Type: Article
Título de Revista/Publicación: Frontiers in Aging Neuroscience
Date: June 2014
ISSN: 1663-4365
Volume: 6
Subjects:
Freetext Keywords: Brain efficiency, cognitive reserve, functional connectivity, healthy aging, MEG
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The proportion of elderly people in the population has increased rapidly in the last century and consequently "healthy aging" is expected to become a critical area of research in neuroscience. Evidence reveals how healthy aging depends on three main behavioral factors: social lifestyle, cognitive activity and physical activity. In this study, we focused on the role of cognitive activity, concentrating specifically on educational and occupational attainment factors, which were considered two of the main pillars of cognitive reserve. 21 subjects with similar rates of social lifestyle, physical and cognitive activity were selected from a sample of 55 healthy adults. These subjects were divided into two groups according to their level of cognitive reserve; one group comprised subjects with high cognitive reserve (9 members) and the other contained those with low cognitive reserve (12 members). To evaluate the cortical brain connectivity network, all participants were recorded by Magnetoencephalography (MEG) while they performed a memory task (modified version of the Sternberg¿s Task). We then applied two algorithms (Phase Locking Value & Phase-Lag Index) to study the dynamics of functional connectivity. In response to the same task, the subjects with lower cognitive reserve presented higher functional connectivity than those with higher cognitive reserve. These results may indicate that participants with low cognitive reserve needed a greater 'effort' than those with high cognitive reserve to achieve the same level of cognitive performance. Therefore, we conclude that cognitive reserve contributes to the modulation of the functional connectivity patterns of the aging brain.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainFPU AP-2008-00175UnspecifiedUnspecifiedUnspecified
Government of SpainPSI2009-14415-C03UnspecifiedUnspecifiedUnspecified
Government of SpainTEC2012-38453-C04-01UnspecifiedUnspecifiedUnspecified
Government of SpainPSI2012-38375-C03-01UnspecifiedUnspecifiedUnspecified

More information

Item ID: 35588
DC Identifier: http://oa.upm.es/35588/
OAI Identifier: oai:oa.upm.es:35588
DOI: 10.3389/fnagi.2014.00125
Official URL: http://journal.frontiersin.org/article/10.3389/fnagi.2014.00125/abstract
Deposited by: Memoria Investigacion
Deposited on: 15 Jun 2015 07:14
Last Modified: 16 May 2019 11:41
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