Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study

López García, María Eugenia; Garcés López, Mª Pilar; Cuesta Prieto, Pablo; Perales Castellanos, Nazareth; Aurtenetxe, Sara; Bajo Breton, Ricardo; Pozo Guerrero, Francisco Del; Sancho, Miguel y Maestú Unturbe, Fernando (2014). Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study. "AGE" ; pp. 1-18. ISSN 0161-9152. https://doi.org/10.1007/s11357-014-9643-2.

Descripción

Título: Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study
Autor/es:
  • López García, María Eugenia
  • Garcés López, Mª Pilar
  • Cuesta Prieto, Pablo
  • Perales Castellanos, Nazareth
  • Aurtenetxe, Sara
  • Bajo Breton, Ricardo
  • Pozo Guerrero, Francisco Del
  • Sancho, Miguel
  • Maestú Unturbe, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: AGE
Fecha: 10 Marzo 2014
Materias:
Palabras Clave Informales: Mild cognitive impairment • Internally directed cognitive state (IDICS)- Functional connectivity- MEG - CRUNCH
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Tecnología Fotónica y Bioingeniería
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Mild Cognitive Impairment (MCI) is a stage between healthy aging and dementia. Functional connectivity is widely used to study the brain activity during resting state or cognitive tasks. We aimed to determine the functional connectivity changes required to deal with an Internally Directed Cognitive State (IDICS) in healthy aging and MCI. This task differs from the most commonly employed in Magnetoencephalograpy (MEG)/ Electroencephalography (EEG), since inhibition from external stimuli is needed, and it allows the study of this control mechanism in healthy and pathological aging. To this end, MEG signals were acquired from 32 healthy individuals and 38 MCI patients, both in resting state and while performing a subtraction task of two levels of difficulty. Phase Locking Value (PLV) was calculated for five frequency bands: delta, theta, alpha, beta and gamma. Synchronization patterns changed in both groups while performing the task. MCI patients presented higher connectivity changes than those in the control group, and this was related to a lower cognitive performance. In particular, in MCIs a hypersynchronization in delta, theta, beta and gamma bands was found, which reveals an abnormal functioning in this group. Contrary to controls, MCIs presented a lack of synchronization in the alpha band which may denote an inhibition deficit. Additionally, the magnitude of connectivity changes rose with the task difficulty in controls but not in MCIs, in line with the CRUNCH model (Compensation-Related Utilization of Neural Circuits Hypothesis).

Proyectos asociados

TipoCódigoAcrónimoResponsableTítulo
Gobierno de EspañaPSI2009-14415-C03-01Sin especificarSin especificarSin especificar
Gobierno de EspañaFPU AP-2008-00175Sin especificarSin especificarSin especificar

Más información

ID de Registro: 35590
Identificador DC: http://oa.upm.es/35590/
Identificador OAI: oai:oa.upm.es:35590
Identificador DOI: 10.1007/s11357-014-9643-2
URL Oficial: http://link.springer.com/article/10.1007/s11357-014-9643-2
Depositado por: Memoria Investigacion
Depositado el: 24 Abr 2017 16:41
Ultima Modificación: 24 Abr 2017 16:41
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