Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study

López García, María Eugenia and Garcés López, Mª Pilar and Cuesta Prieto, Pablo and Perales Castellanos, Nazareth and Aurtenetxe, Sara and Bajo Breton, Ricardo and Pozo Guerrero, Francisco Del and Sancho, Miguel and Maestú Unturbe, Fernando (2014). Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study. "AGE" ; pp. 1-18. ISSN 0161-9152. https://doi.org/10.1007/s11357-014-9643-2.

Description

Title: Synchronization during an internally directed cognitive state in healthy aging and mild cognitive impairment: a MEG study
Author/s:
  • López García, María Eugenia
  • Garcés López, Mª Pilar
  • Cuesta Prieto, Pablo
  • Perales Castellanos, Nazareth
  • Aurtenetxe, Sara
  • Bajo Breton, Ricardo
  • Pozo Guerrero, Francisco Del
  • Sancho, Miguel
  • Maestú Unturbe, Fernando
Item Type: Article
Título de Revista/Publicación: AGE
Date: 10 March 2014
Subjects:
Freetext Keywords: Mild cognitive impairment • Internally directed cognitive state (IDICS)- Functional connectivity- MEG - CRUNCH
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Mild Cognitive Impairment (MCI) is a stage between healthy aging and dementia. Functional connectivity is widely used to study the brain activity during resting state or cognitive tasks. We aimed to determine the functional connectivity changes required to deal with an Internally Directed Cognitive State (IDICS) in healthy aging and MCI. This task differs from the most commonly employed in Magnetoencephalograpy (MEG)/ Electroencephalography (EEG), since inhibition from external stimuli is needed, and it allows the study of this control mechanism in healthy and pathological aging. To this end, MEG signals were acquired from 32 healthy individuals and 38 MCI patients, both in resting state and while performing a subtraction task of two levels of difficulty. Phase Locking Value (PLV) was calculated for five frequency bands: delta, theta, alpha, beta and gamma. Synchronization patterns changed in both groups while performing the task. MCI patients presented higher connectivity changes than those in the control group, and this was related to a lower cognitive performance. In particular, in MCIs a hypersynchronization in delta, theta, beta and gamma bands was found, which reveals an abnormal functioning in this group. Contrary to controls, MCIs presented a lack of synchronization in the alpha band which may denote an inhibition deficit. Additionally, the magnitude of connectivity changes rose with the task difficulty in controls but not in MCIs, in line with the CRUNCH model (Compensation-Related Utilization of Neural Circuits Hypothesis).

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainPSI2009-14415-C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainFPU AP-2008-00175UnspecifiedUnspecifiedUnspecified
Government of SpainPSI2012-38375-C03-01UnspecifiedUnspecifiedUnspecified
Government of SpainBES-2010-036469UnspecifiedUnspecifiedUnspecified

More information

Item ID: 35590
DC Identifier: http://oa.upm.es/35590/
OAI Identifier: oai:oa.upm.es:35590
DOI: 10.1007/s11357-014-9643-2
Official URL: http://link.springer.com/article/10.1007/s11357-014-9643-2
Deposited by: Memoria Investigacion
Deposited on: 24 Apr 2017 16:41
Last Modified: 16 May 2019 11:44
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