Alternative neural circuitry that might be impaired in the development of Alzheimer disease

Ávila, Jesús and Perry, George and Strange, Bryan A. and Hernández, Félix (2015). Alternative neural circuitry that might be impaired in the development of Alzheimer disease. "Frontiers in Neuroscience", v. 9 (n. 145); pp. 1-5. ISSN 1662-4548. https://doi.org/10.3389/fnins.2015.00145.

Description

Title: Alternative neural circuitry that might be impaired in the development of Alzheimer disease
Author/s:
  • Ávila, Jesús
  • Perry, George
  • Strange, Bryan A.
  • Hernández, Félix
Item Type: Article
Título de Revista/Publicación: Frontiers in Neuroscience
Date: April 2015
ISSN: 1662-4548
Volume: 9
Subjects:
Freetext Keywords: Alzheimer disease (AD), cognitive decline, tau proteins, abeta, tauopathies
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

It is well established that some individuals with normal cognitive capacity have abundant senile plaques in their brains. It has been proposed that those individuals are resilient or have compensation factors to prevent cognitive decline. In this comment, we explore an alternative mechanism through which cognitive capacity is maintained. This mechanism could involve the impairment of alternative neural circuitry. Also, the proportion of molecules such as A? or tau protein present in different areas of the brain could be important.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainSAF 2011-24841UnspecifiedMinisterio de SanidadUnspecified
Government of SpainBFU-2008-03980UnspecifiedMinisterio de SanidadUnspecified
Government of SpainBFU-2010-21507UnspecifiedMinisterio de SanidadUnspecified
Madrid Regional GovernmentSA2010/BMD2331UnspecifiedUnspecifiedUnspecified

More information

Item ID: 41066
DC Identifier: http://oa.upm.es/41066/
OAI Identifier: oai:oa.upm.es:41066
DOI: 10.3389/fnins.2015.00145
Official URL: http://journal.frontiersin.org/article/10.3389/fnins.2015.00145/full
Deposited by: Memoria Investigacion
Deposited on: 20 Jun 2016 18:10
Last Modified: 06 Jun 2019 14:06
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