Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion

Barios Heredero, Juan Antonio; Pisarchyk, Liudmila; Fernández García, Laura; C. Barrio, Luis; Ramos Gomez, Milagros; Martínez Murillo, Ricardo y González Nieto, Daniel (2016). Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion. "Journal of Cerebral Blood Flow & Metabolism", v. 36 (n. 3); pp. 606-620. ISSN 0271-678X. https://doi.org/10.1177/0271678X15606139.

Descripción

Título: Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion
Autor/es:
  • Barios Heredero, Juan Antonio
  • Pisarchyk, Liudmila
  • Fernández García, Laura
  • C. Barrio, Luis
  • Ramos Gomez, Milagros
  • Martínez Murillo, Ricardo
  • González Nieto, Daniel
Tipo de Documento: Artículo
Título de Revista/Publicación: Journal of Cerebral Blood Flow & Metabolism
Fecha: Marzo 2016
Volumen: 36
Materias:
Palabras Clave Informales: Behavior, somatosensory evoked potentials, stroke neuroprotection and repair
Escuela: Centro de Tecnología Biomédica (CTB) (UPM)
Departamento: Tecnología Fotónica y Bioingeniería
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

A constant challenge in experimental stroke is the use of appropriate tests to identify signs of recovery and adverse effects linked to a particular therapy. In this study, we used a long-term longitudinal approach to examine the functional brain changes associated with cortical infarction in a mouse model induced by permanent ligation of the middle cerebral artery (MCA). Sensorimotor function and somatosensory cortical activity were evaluated with fault-foot and forelimb asymmetry tests in combination with somatosensory evoked potentials. The stroke mice exhibited both long-term deficits in the functional tests and impaired responses in the infarcted and intact hemispheres after contralateral and ipsilateral forepaw stimulation. In the infarcted hemisphere, reductions in the amplitudes of evoked responses were detected after contralateral and ipsilateral stimulation. In the intact hemisphere, and similar to cortical stroke patients, a gradual hyperexcitability was observed after contralateral stimulation but no parallel evidence of a response was detected after ipsilateral stimulation. Our results suggest the existence of profound and persistent changes in the somatosensory cortex in this specific mouse cortical stroke model. The study of evoked potentials constitutes a feasible and excellent tool for evaluating the fitness of the somatosensory cortex in relation to functional recovery after preclinical therapeutic intervention.

Proyectos asociados

TipoCódigoAcrónimoResponsableTítulo
Comunidad de MadridGrant Neurotec-S2010/BMD-2460Sin especificarSin especificarSin especificar
Gobierno de EspañaCSD2008-00005Sin especificarSin especificarSin especificar

Más información

ID de Registro: 41082
Identificador DC: http://oa.upm.es/41082/
Identificador OAI: oai:oa.upm.es:41082
Identificador DOI: 10.1177/0271678X15606139
URL Oficial: http://jcb.sagepub.com/content/36/3/606
Depositado por: Memoria Investigacion
Depositado el: 29 Abr 2017 10:46
Ultima Modificación: 29 Abr 2017 10:46
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