Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion

Barios Heredero, Juan Antonio and Pisarchyk, Liudmila and Fernández García, Laura and C. Barrio, Luis and Ramos Gomez, Milagros and Martínez Murillo, Ricardo and González Nieto, Daniel (2016). Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion. "Journal of Cerebral Blood Flow & Metabolism", v. 36 (n. 3); pp. 606-620. ISSN 0271-678X. https://doi.org/10.1177/0271678X15606139.

Description

Title: Long-term dynamics of somatosensory activity in a stroke model of distal middle cerebral artery oclussion
Author/s:
  • Barios Heredero, Juan Antonio
  • Pisarchyk, Liudmila
  • Fernández García, Laura
  • C. Barrio, Luis
  • Ramos Gomez, Milagros
  • Martínez Murillo, Ricardo
  • González Nieto, Daniel
Item Type: Article
Título de Revista/Publicación: Journal of Cerebral Blood Flow & Metabolism
Date: March 2016
Volume: 36
Subjects:
Freetext Keywords: Behavior, somatosensory evoked potentials, stroke neuroprotection and repair
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

A constant challenge in experimental stroke is the use of appropriate tests to identify signs of recovery and adverse effects linked to a particular therapy. In this study, we used a long-term longitudinal approach to examine the functional brain changes associated with cortical infarction in a mouse model induced by permanent ligation of the middle cerebral artery (MCA). Sensorimotor function and somatosensory cortical activity were evaluated with fault-foot and forelimb asymmetry tests in combination with somatosensory evoked potentials. The stroke mice exhibited both long-term deficits in the functional tests and impaired responses in the infarcted and intact hemispheres after contralateral and ipsilateral forepaw stimulation. In the infarcted hemisphere, reductions in the amplitudes of evoked responses were detected after contralateral and ipsilateral stimulation. In the intact hemisphere, and similar to cortical stroke patients, a gradual hyperexcitability was observed after contralateral stimulation but no parallel evidence of a response was detected after ipsilateral stimulation. Our results suggest the existence of profound and persistent changes in the somatosensory cortex in this specific mouse cortical stroke model. The study of evoked potentials constitutes a feasible and excellent tool for evaluating the fitness of the somatosensory cortex in relation to functional recovery after preclinical therapeutic intervention.

Funding Projects

TypeCodeAcronymLeaderTitle
Madrid Regional GovernmentGrant Neurotec-S2010/BMD-2460UnspecifiedUnspecifiedUnspecified
Government of SpainCSD2008-00005UnspecifiedUnspecifiedUnspecified

More information

Item ID: 41082
DC Identifier: http://oa.upm.es/41082/
OAI Identifier: oai:oa.upm.es:41082
DOI: 10.1177/0271678X15606139
Official URL: https://doi.org/10.1177/0271678X15606139
Deposited by: Memoria Investigacion
Deposited on: 29 Apr 2017 10:46
Last Modified: 14 Mar 2019 15:31
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