Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus

Aoki, Yasunori and Hiroaki, Kazui and Toshihisa, Tanaka and Ishii, Ryouhei and Wada, Tamiki and Ikeda, Shunichiro and Hata, Masahiro and Canuet Delis, Leonides and Themistoklis, Katsimichas and Musha, Toshimitsu and Matsuzaki, Haruyasu and Imajo, Kaoru and Kanemoto, Hideki and Yoshida, Tetsuhiko and Nomura, Keiko and Yoshiyama, Kenji and Iwase, Masao and Takeda, M. (2015). Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus. "Scientific Reports", v. 5 (n. 7775); pp. 1-5. ISSN 2045-2322. https://doi.org/10.1038/srep07775.

Description

Title: Noninvasive prediction of shunt operation outcome in idiopathic normal pressure hydrocephalus
Author/s:
  • Aoki, Yasunori
  • Hiroaki, Kazui
  • Toshihisa, Tanaka
  • Ishii, Ryouhei
  • Wada, Tamiki
  • Ikeda, Shunichiro
  • Hata, Masahiro
  • Canuet Delis, Leonides
  • Themistoklis, Katsimichas
  • Musha, Toshimitsu
  • Matsuzaki, Haruyasu
  • Imajo, Kaoru
  • Kanemoto, Hideki
  • Yoshida, Tetsuhiko
  • Nomura, Keiko
  • Yoshiyama, Kenji
  • Iwase, Masao
  • Takeda, M.
Item Type: Article
Título de Revista/Publicación: Scientific Reports
Date: 14 January 2015
ISSN: 2045-2322
Volume: 5
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Idiopathic normal pressure hydrocephalus (iNPH) is a syndrome characterized by gait disturbance, cognitive deterioration and urinary incontinence in elderly individuals. These symptoms can be improved by shunt operation in some but not all patients. Therefore, discovering predictive factors for the surgical outcome is of great clinical importance. We used normalized power variance (NPV) of electroencephalography (EEG) waves, a sensitive measure of the instability of cortical electrical activity, and found significantly higher NPV in beta frequency band at the right fronto-temporo-occipital electrodes (Fp2, T4 and O2) in shunt responders compared to non-responders. By utilizing these differences, we were able to correctly identify responders and non-responders to shunt operation with a positive predictive value of 80% and a negative predictive value of 88%. Our findings indicate that NPV can be useful in noninvasively predicting the clinical outcome of shunt operation in patients with iNPH.

More information

Item ID: 41086
DC Identifier: http://oa.upm.es/41086/
OAI Identifier: oai:oa.upm.es:41086
DOI: 10.1038/srep07775
Official URL: http://www.nature.com/articles/srep07775
Deposited by: Memoria Investigacion
Deposited on: 22 Apr 2017 12:03
Last Modified: 22 Apr 2017 12:03
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