Mathematical modeling of neuronal connexin-36 channels

Jaimes-Reátegui, Rider and Barrio, Luis C. and González Nieto, Daniel and Pisarchik, Alexander N. (2015). Mathematical modeling of neuronal connexin-36 channels. In: "BBVA Workshop on recent advances in bioinformatics and neuroscience", 09/06/2015 - 11/06/2015, MADRID, SPAIN. p. 1.

Description

Title: Mathematical modeling of neuronal connexin-36 channels
Author/s:
  • Jaimes-Reátegui, Rider
  • Barrio, Luis C.
  • González Nieto, Daniel
  • Pisarchik, Alexander N.
Item Type: Presentation at Congress or Conference (Poster)
Event Title: BBVA Workshop on recent advances in bioinformatics and neuroscience
Event Dates: 09/06/2015 - 11/06/2015
Event Location: MADRID, SPAIN
Title of Book: BBVA Workshop on recent advances in bioinformatics and neuroscience
Date: 2015
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Neurotransmission through electrical synapses play an important role in the spike synchrony among neurons and oscillation of neuron networks. Connexin36 (Cx36) is the principal gap junction protein of electrical synapses between inhibitory interneurons in vertebrates. Coupling strength between coupled neurons is modulated, among other factor, by the voltage difference between cell interiors, termed transjunctional voltage (Vj), in a complex manner; with the Vj gradient junctional conductance of Cx36 channels first increases instantaneously (+ 20% for + 100 mV) and then it decreases slowly to half for a similar range of Vj. The significance of this regulation by voltage, a stimulus always presents and changing, in the firing properties of coupled neurons is unknown.

More information

Item ID: 42263
DC Identifier: http://oa.upm.es/42263/
OAI Identifier: oai:oa.upm.es:42263
Deposited by: Memoria Investigacion
Deposited on: 27 Jun 2016 12:02
Last Modified: 09 May 2017 16:24
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