Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration

Selvas, Abraham; Coria, Santiago M.; Kastanauskaite, Asta; Fernaud Espinosa, Isabel; Felipe Oroquieta, Javier de; Ambrosio, Emilio y Miguens Vázquez, Miguel (2015). Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration. "Addiction Biology", v. 20 (n. 5); pp. 1-15. ISSN 1355-6215. https://doi.org/10.1111/adb.12294.

Descripción

Título: Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Autor/es:
  • Selvas, Abraham
  • Coria, Santiago M.
  • Kastanauskaite, Asta
  • Fernaud Espinosa, Isabel
  • Felipe Oroquieta, Javier de
  • Ambrosio, Emilio
  • Miguens Vázquez, Miguel
Tipo de Documento: Artículo
Título de Revista/Publicación: Addiction Biology
Fecha: Septiembre 2015
Volumen: 20
Materias:
Palabras Clave Informales: 3D neuron analysis; CA1; Fischer 344; Lewis; Genetic background; Intracellular injections
Escuela: E.T.S. de Ingenieros Informáticos (UPM)
Departamento: Inteligencia Artificial
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two strains of rats. Strain-specific differences were observed prior to cocaine self-administration: LEW rats had significantly larger dendritic diameters but lower spine density than the F344 strain. After cocaine self-administration, proximal dendritic volume, dendritic surface area and spine density were increased in LEW rats, where a higher percentage of larger spines were also observed. In addition, we found a strong positive correlation between dendritic volume and spine morphology, and a moderate correlation between dendritic volume and spine density in cocaine self-administered LEW rats, an effect that was not evident in any other condition. By contrast, after cocaine self-administration, F334 rats showed decreased spine head volumes. Our findings suggest that genetic differences could play a key role in the structural plasticity induced by cocaine in CA1 pyramidal neurons. These cocaine-induced alterations could be related to differences in the memory processing of drug reward cues that could potentially explain differential individual vulnerability to cocaine addiction.

Más información

ID de Registro: 43874
Identificador DC: http://oa.upm.es/43874/
Identificador OAI: oai:oa.upm.es:43874
Identificador DOI: 10.1111/adb.12294
URL Oficial: http://onlinelibrary.wiley.com/doi/10.1111/adb.12294/abstract;jsessionid=D6ABAC4FBF2BFBADA914C2E581293EA3.f01t02
Depositado por: Memoria Investigacion
Depositado el: 19 Dic 2016 15:29
Ultima Modificación: 19 Dic 2016 15:29
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