Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration

Selvas, Abraham and Coria, Santiago M. and Kastanauskaite, Asta and Fernaud Espinosa, Isabel and Felipe Oroquieta, Javier de and Ambrosio, Emilio and Miguens Vázquez, Miguel (2015). Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration. "Addiction Biology", v. 20 (n. 5); pp. 1-15. ISSN 1355-6215. https://doi.org/10.1111/adb.12294.

Description

Title: Rat-strain dependent changes of dendritic and spine morphology in the hippocampus after cocaine self-administration
Author/s:
  • Selvas, Abraham
  • Coria, Santiago M.
  • Kastanauskaite, Asta
  • Fernaud Espinosa, Isabel
  • Felipe Oroquieta, Javier de
  • Ambrosio, Emilio
  • Miguens Vázquez, Miguel
Item Type: Article
Título de Revista/Publicación: Addiction Biology
Date: September 2015
ISSN: 1355-6215
Volume: 20
Subjects:
Freetext Keywords: 3D neuron analysis; CA1; Fischer 344; Lewis; Genetic background; Intracellular injections
Faculty: E.T.S. de Ingenieros Informáticos (UPM)
Department: Inteligencia Artificial
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (1MB) | Preview

Abstract

We previously showed that cocaine self-administration increases spine density in CA1 hippocampal neurons in Lewis (LEW) but not in Fischer 344 (F344) rats. Dendritic spine morphology is intimately related to its function. Thus, we conducted a 3D morphological analysis of CA1 dendrites and dendritic spines in these two strains of rats. Strain-specific differences were observed prior to cocaine self-administration: LEW rats had significantly larger dendritic diameters but lower spine density than the F344 strain. After cocaine self-administration, proximal dendritic volume, dendritic surface area and spine density were increased in LEW rats, where a higher percentage of larger spines were also observed. In addition, we found a strong positive correlation between dendritic volume and spine morphology, and a moderate correlation between dendritic volume and spine density in cocaine self-administered LEW rats, an effect that was not evident in any other condition. By contrast, after cocaine self-administration, F334 rats showed decreased spine head volumes. Our findings suggest that genetic differences could play a key role in the structural plasticity induced by cocaine in CA1 pyramidal neurons. These cocaine-induced alterations could be related to differences in the memory processing of drug reward cues that could potentially explain differential individual vulnerability to cocaine addiction.

More information

Item ID: 43874
DC Identifier: http://oa.upm.es/43874/
OAI Identifier: oai:oa.upm.es:43874
DOI: 10.1111/adb.12294
Official URL: http://onlinelibrary.wiley.com/doi/10.1111/adb.12294/abstract;jsessionid=D6ABAC4FBF2BFBADA914C2E581293EA3.f01t02
Deposited by: Memoria Investigacion
Deposited on: 19 Dec 2016 15:29
Last Modified: 19 Dec 2016 15:29
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM