Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases

Carvajal Ahumada, Luis Armando and Rivera González, Marco Xavier and Herrera Sandoval, Oscar Leonardo and Serrano Olmedo, Jose Javier (2016). Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases. "Sensors", v. 16 (n. 11); pp. 1-16. ISSN 1424-8220. https://doi.org/10.3390/s16111959.

Description

Title: Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases
Author/s:
  • Carvajal Ahumada, Luis Armando
  • Rivera González, Marco Xavier
  • Herrera Sandoval, Oscar Leonardo
  • Serrano Olmedo, Jose Javier
Item Type: Article
Título de Revista/Publicación: Sensors
Date: November 2016
Volume: 16
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid. Due to the viscoelastic and pseudo-plastic behavior of hyaluronic acid, it is necessary to use the Rouse model in order to obtain viscosity values comparable with viscometer measures. A Fungilab viscometer (rheometer) was used to obtain reference measures of the viscosity in each sample in order to compare them with the QCR prototype measures.

More information

Item ID: 45021
DC Identifier: http://oa.upm.es/45021/
OAI Identifier: oai:oa.upm.es:45021
DOI: 10.3390/s16111959
Official URL: http://www.mdpi.com/1424-8220/16/11/1959
Deposited by: Memoria Investigacion
Deposited on: 06 Mar 2017 12:41
Last Modified: 26 Apr 2017 18:16
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