Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

Díaz Lantada, Andrés; Alarcón Iniesta, Hernán y García-Ruíz, Josefa Predestinación (2016). Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization. "Materials Science and Engineering: C", v. 59 ; pp. 218-227. ISSN 0928-4931. https://doi.org/10.1016/j.msec.2015.10.015.

Descripción

Título: Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization
Autor/es:
  • Díaz Lantada, Andrés
  • Alarcón Iniesta, Hernán
  • García-Ruíz, Josefa Predestinación
Tipo de Documento: Artículo
Título de Revista/Publicación: Materials Science and Engineering: C
Fecha: 1 Febrero 2016
Volumen: 59
Materias:
Palabras Clave Informales: Tissue engineering, Scaffolds for tissue repair, Osteochondral repair, Rapid prototyping, Additive manufacture, Computer-aided design & engineering
Escuela: E.T.S.I. Industriales (UPM)
Departamento: Ingeniería Mecánica
Grupo Investigación UPM: Product Development Laboratory
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Articular repair is a relevant and challenging area for the emerging fields of tissue engineering and biofabrication. The need of significant gradients of properties, for the promotion of osteochondral repair, has led to the development of several families of composite biomaterials and scaffolds, using different effective approaches, although a perfect solution has not yet been found. In this study we present the design, modeling, rapid manufacturing and in vitro testing of a composite scaffold aimed at osteochondral repair. The presented composite scaffold stands out for having a functional gradient of density and stiffness in the bony phase, obtained in titanium by means of computer-aided design combined with additive manufacture using selective laser sintering. The chondral phase is obtained by sugar leaching, using a PDMS matrix and sugar as porogen, and is joined to the bony phase during the polymerization of PDMS, therefore avoiding the use of supporting adhesives or additional intermediate layers. The mechanical performance of the construct is biomimetic and the stiffness values of the bony and chondral phases can be tuned to the desired applications, by means of controlled modifications of different parameters. A humanmesenchymal stemcell (h-MSC) conditionedmedium(CM) is used for improving scaffold response. Cell culture results provide relevant information regarding the viability of the composite scaffolds used.

Más información

ID de Registro: 45964
Identificador DC: http://oa.upm.es/45964/
Identificador OAI: oai:oa.upm.es:45964
Identificador DOI: 10.1016/j.msec.2015.10.015
URL Oficial: http://www.sciencedirect.com/science/article/pii/S0928493115304458
Depositado por: Memoria Investigacion
Depositado el: 22 May 2017 15:56
Ultima Modificación: 22 May 2017 15:56
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