Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

Díaz Lantada, Andrés and Alarcón Iniesta, Hernán and García-Ruíz, Josefa Predestinación (2016). Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization. "Materials Science and Engineering: C", v. 59 ; pp. 218-227. ISSN 0928-4931. https://doi.org/10.1016/j.msec.2015.10.015.

Description

Title: Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization
Author/s:
  • Díaz Lantada, Andrés
  • Alarcón Iniesta, Hernán
  • García-Ruíz, Josefa Predestinación
Item Type: Article
Título de Revista/Publicación: Materials Science and Engineering: C
Date: 1 February 2016
Volume: 59
Subjects:
Freetext Keywords: Tissue engineering, Scaffolds for tissue repair, Osteochondral repair, Rapid prototyping, Additive manufacture, Computer-aided design & engineering
Faculty: E.T.S.I. Industriales (UPM)
Department: Ingeniería Mecánica
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Articular repair is a relevant and challenging area for the emerging fields of tissue engineering and biofabrication. The need of significant gradients of properties, for the promotion of osteochondral repair, has led to the development of several families of composite biomaterials and scaffolds, using different effective approaches, although a perfect solution has not yet been found. In this study we present the design, modeling, rapid manufacturing and in vitro testing of a composite scaffold aimed at osteochondral repair. The presented composite scaffold stands out for having a functional gradient of density and stiffness in the bony phase, obtained in titanium by means of computer-aided design combined with additive manufacture using selective laser sintering. The chondral phase is obtained by sugar leaching, using a PDMS matrix and sugar as porogen, and is joined to the bony phase during the polymerization of PDMS, therefore avoiding the use of supporting adhesives or additional intermediate layers. The mechanical performance of the construct is biomimetic and the stiffness values of the bony and chondral phases can be tuned to the desired applications, by means of controlled modifications of different parameters. A humanmesenchymal stemcell (h-MSC) conditionedmedium(CM) is used for improving scaffold response. Cell culture results provide relevant information regarding the viability of the composite scaffolds used.

More information

Item ID: 45964
DC Identifier: http://oa.upm.es/45964/
OAI Identifier: oai:oa.upm.es:45964
DOI: 10.1016/j.msec.2015.10.015
Official URL: http://www.sciencedirect.com/science/article/pii/S0928493115304458
Deposited by: Memoria Investigacion
Deposited on: 22 May 2017 15:56
Last Modified: 04 Jun 2019 11:20
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