The effect of cellobiose on the health status of growing rabbits depends on the dietary level of soluble fiber

Ocasio Vega, C. and Delgado, R. and Abad Guaman, Rodrigo and Carabaño Luengo, Rosa Maria and Carro Travieso, Maria Dolores and Menoyo Luque, David and Garcia Alonso, Javier (2018). The effect of cellobiose on the health status of growing rabbits depends on the dietary level of soluble fiber. "Journal of Animal Science", v. 96 (n. 5); pp. 1806-1817. ISSN 0021-8812. https://doi.org/10.1093/jas/sky106.

Description

Title: The effect of cellobiose on the health status of growing rabbits depends on the dietary level of soluble fiber
Author/s:
  • Ocasio Vega, C.
  • Delgado, R.
  • Abad Guaman, Rodrigo
  • Carabaño Luengo, Rosa Maria
  • Carro Travieso, Maria Dolores
  • Menoyo Luque, David
  • Garcia Alonso, Javier
Item Type: Article
Título de Revista/Publicación: Journal of Animal Science
Date: May 2018
ISSN: 0021-8812
Volume: 96
Subjects:
Freetext Keywords: cellobiose; immune response; rabbit; soluble dietary fiber; volatile fatty acids
Faculty: E.T.S. de Ingeniería Agronómica, Alimentaria y de Biosistemas (UPM)
Department: Otro
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The aim of this study was to examine whether the combination of dietary soluble fiber and cellobiose exerts a synergistic effect on growth performance, health status, fermentation traits, and immune response in rabbits. Six treatments in a 3 × 2 factorial arrangement were used: 3 cellobiose concentrations in drinking water (0.0, 7.5, and 15.0 g/L) × 2 dietary levels of soluble fiber (84.0 and 130 g/kg DM, for the low soluble fiber [LSF] and high soluble fiber [HSF] diets, respectively). A total of 318 young rabbits (53/treatment) were weaned at 34 d of age and had ad libitum access to feed and water. At 46 d of age, 9 rabbits/treatment were slaughtered and ileal and cecal digesta were collected to analyze VFA profile and the immune response in the cecal appendix mucosa. At 48 d of age, the cellobiose supplementation was withdrawn and the experimental diets were replaced by a standard commercial diet until 61 d of age. From 34 to 48 d of age, there was a linear increase of mortality with the level of cellobiose in the HSF group (0% vs. 17.1%; P = 0.017). In contrast, a quadratic effect of cellobiose level on mortality was observed in the LSF group, the rabbits offered 7.5-cellobiose showing the lowest mortality (5.7% vs. 21.4%; P = 0.030). Cellobiose level had a quadratic effect on ADFI, ADG, and G:F in this period (P ≤ 0.047), with the 7.5-cellobiose groups having the best growth performance. In contrast, only minor changes on these traits were observed from 48 d of age onwards. Cellobiose level influenced quadratically the ileal VFA concentrations (P = 0.014), showing the maximal value in the 7.5-cellobiose groups. In rabbits fed 7.5-cellobiose-LSF, a change of acetate to propionate, butyrate, and valerate was observed in the ileum. Increasing cellobiose levels reduced linearly cecal VFA concentrations in HSF fed rabbits, but no effect was detected in LSF groups (P = 0.046). The level of soluble fiber increased VFA concentrations in both the ileum (by 22%; P < 0.001), and the cecum (by 11%; P = 0.005). The relative gene expression of IL-6, IL-10, TNF-α, iNOS, MUC-1, and toll-like receptors (TLR-2 and TLR-4) in the cecal appendix increased linear and quadratically with increasing levels of cellobiose (P ≤ 0.063). In conclusion, in rabbits fed LSF diets, a dose of 7.5 g cellobiose/L drinking water would be recommended, whereas these levels of cellobiose supplementation should be avoided in rabbits fed HSF diets.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainAGL2011-23885UnspecifiedUnspecifiedNutrientes inmunoestimuladores en gazapos
Madrid Regional GovernmentS2013/ABI-2913MEDGANUnspecifiedTecnologías de manejo, nutrición y genética para optimizar la producción de alimentos de origen animal característicos de la dieta mediterránea

More information

Item ID: 54587
DC Identifier: http://oa.upm.es/54587/
OAI Identifier: oai:oa.upm.es:54587
DOI: 10.1093/jas/sky106
Official URL: https://academic.oup.com/jas/article-abstract/96/5/1806/4960001?redirectedFrom=fulltext
Deposited by: Memoria Investigacion
Deposited on: 11 Apr 2019 11:35
Last Modified: 01 Jun 2019 22:30
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