Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans

Galarza Vallejo, Ana and Kroes, Marijn C. W. and Rey Díaz-Rubio, Enrique and Acedo Díaz-Pache, María Victoria and Moratti, Stephan and Fernández Reumann, Guillén and Strange, Bryan A. (2019). Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans. "Science Advances", v. 5 (n. 3); pp. 3801-3810. ISSN 2375-2548. https://doi.org/10.1126/sciadv.aav3801.

Description

Title: Propofol-induced deep sedation reduces emotional episodic memory reconsolidation in humans
Author/s:
  • Galarza Vallejo, Ana
  • Kroes, Marijn C. W.
  • Rey Díaz-Rubio, Enrique
  • Acedo Díaz-Pache, María Victoria
  • Moratti, Stephan
  • Fernández Reumann, Guillén
  • Strange, Bryan A.
Item Type: Article
Título de Revista/Publicación: Science Advances
Date: March 2019
ISSN: 2375-2548
Volume: 5
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The adjustment of maladaptive thoughts and behaviors associated with emotional memories is central to treating psychiatric disorders. Recent research, predominantly with laboratory animals, indicates that memories can become temporarily sensitive to modification following reactivation, before undergoing reconsolidation. A method to selectively impair reconsolidation of specific emotional or traumatic memories in humans could translate to an effective treatment for conditions such as posttraumatic stress disorder. We tested whether deep sedation could impair emotional memory reconsolidation in 50 human participants. Administering the intravenous anesthetic propofol following memory reactivation disrupted memory for the reactivated, but not for a non-reactivated, slideshow story. Propofol impaired memory for the reactivated story after 24 hours, but not immediately after propofol recovery. Critically, memory impairment occurred selectively for the emotionally negative phase of the reactivated story. One dose of propofol following memory reactivation selectively impaired subsequent emotional episodic memory retrieval in a time-dependent manner, consistent with reconsolidation impairment.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainSAF2014-62116-EXPUnspecifiedUnspecifiedUnspecified
Government of SpainSAF2015-65982-RUnspecifiedUnspecifiedAumento de memoria en seres humanos mediante estimulación cerebral profunda del núcleo accumbens
FP7304248EMOTIONCOGUNIVERSIDAD POLITECNICA DE MADRIDExploring the Effects of Emotion on Human Cognition

More information

Item ID: 63164
DC Identifier: http://oa.upm.es/63164/
OAI Identifier: oai:oa.upm.es:63164
DOI: 10.1126/sciadv.aav3801
Official URL: https://advances.sciencemag.org/content/5/3/eaav3801
Deposited by: Memoria Investigacion
Deposited on: 01 Nov 2020 10:10
Last Modified: 01 Nov 2020 10:10
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