Comparative study of quantitative scales for the evaluation of treatment response in Hodgkin lymphoma

Quiles Franquet, José María and Seiffert, Alexander Peter and Hernández Martínez, Ana Cristina and Gómez Grande, Adolfo and Gómez Aguilera, Enrique J. and Sánchez González, Patricia (2019). Comparative study of quantitative scales for the evaluation of treatment response in Hodgkin lymphoma. In: "XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019", 27/11/2019 - 29/11/2019, Santander, España. ISBN 978-84-09-16707-4. pp. 223-226.

Description

Title: Comparative study of quantitative scales for the evaluation of treatment response in Hodgkin lymphoma
Author/s:
  • Quiles Franquet, José María
  • Seiffert, Alexander Peter
  • Hernández Martínez, Ana Cristina
  • Gómez Grande, Adolfo
  • Gómez Aguilera, Enrique J.
  • Sánchez González, Patricia
Item Type: Presentation at Congress or Conference (Article)
Event Title: XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019
Event Dates: 27/11/2019 - 29/11/2019
Event Location: Santander, España
Title of Book: Actas del XXXVII Congreso Anual de la Sociedad Española de Ingeniería Biomédica, CASEIB 2019
Date: 2019
ISBN: 978-84-09-16707-4
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Hodgkin lymphoma (HL) is a type of blood cancer that generally originates in the lymph nodes and can spread within the lymphatic system. HL is highly curable and treated usually by chemotherapy following the ABVD (Adrymacin, Bleomycin, Vinblastine and Dacarbazine) regime. The evaluation of the response to the treatment of the patients is performed by the visual analysis of interim and end-of-treatment 18Ffluorodeoxyglucose (FDG) positron emission tomography (PET) images. The Deauville five-point scale is the internationally recommended tool to assess patient response. However, this scale is based on a visual analysis of PET-FDG images. Semiquantitative scales, called rPET and qPET that are based on the Standardized Uptake Value (SUV), have previously been proposed for a more objective classification of the cases. A graphical user interface is developed to manually select the lesions in PET images, process the images and automatically calculate the Deauville score based on the rPET and qPET scales. The algorithm is validated by analysing 9 cases of patients diagnosed with HL. The obtained Deauville scores are compared to the evaluation of the images by two physicians specialized in nuclear medicine. In 94.44% and 100% of the cases that are classified with the rPET and qPET scales, respectively, the result matches the visual analysis. The results obtained with both parameters could potentially indicate their viability in assessing the response to treatment in HL patients.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainFPU16/06487UnspecifiedUnspecifiedBeca de Formación de Profesorado Universitario

More information

Item ID: 63222
DC Identifier: http://oa.upm.es/63222/
OAI Identifier: oai:oa.upm.es:63222
Official URL: http://caseib.es/2019/
Deposited by: Memoria Investigacion
Deposited on: 04 Nov 2020 15:40
Last Modified: 04 Nov 2020 15:40
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