Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?

Beslon, Guillaume and Parsons, David and Sanchez Dehesa, Yolanda and Peña Sanchez, Jose Maria and Knibbeb, Carole (2010). Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?. "Biosystems", v. 102 (n. 1); pp. 32-40. ISSN 0303-2647. https://doi.org/10.1016/j.biosystems.2010.07.009.

Description

Title: Scaling laws in bacterial genomes: A side-effect of selection of mutational robustness?
Author/s:
  • Beslon, Guillaume
  • Parsons, David
  • Sanchez Dehesa, Yolanda
  • Peña Sanchez, Jose Maria
  • Knibbeb, Carole
Item Type: Article
Título de Revista/Publicación: Biosystems
Date: October 2010
ISSN: 0303-2647
Volume: 102
Subjects:
Freetext Keywords: Modelling; Scaling laws; Gene content; Transcription Factors; Mutational robustness; Evolvability
Faculty: Facultad de Informática (UPM)
Department: Arquitectura y Tecnología de Sistemas Informáticos
Creative Commons Licenses: Recognition - No derivative works - Non commercial

Full text

[img]
Preview
PDF - Requires a PDF viewer, such as GSview, Xpdf or Adobe Acrobat Reader
Download (560kB) | Preview

Abstract

In the past few years, numerous research projects have focused on identifying and understanding scaling properties in the gene content of prokaryote genomes and the intricacy of their regulation networks. Yet, and despite the increasing amount of data available, the origins of these scalings remain an open question. The RAevol model, a digital genetics model, provides us with an insight into the mechanisms involved in an evolutionary process. The results we present here show that (i) our model reproduces qualitatively these scaling laws and that (ii) these laws are not due to differences in lifestyles but to differences in the spontaneous rates of mutations and rearrangements. We argue that this is due to an indirect selective pressure for robustness that constrains the genome size.

More information

Item ID: 7241
DC Identifier: http://oa.upm.es/7241/
OAI Identifier: oai:oa.upm.es:7241
DOI: 10.1016/j.biosystems.2010.07.009
Official URL: http://www.sciencedirect.com/science/article/pii/S0303264710001176
Deposited by: Memoria Investigacion
Deposited on: 14 Jun 2011 10:29
Last Modified: 20 Apr 2016 16:25
  • Logo InvestigaM (UPM)
  • Logo GEOUP4
  • Logo Open Access
  • Open Access
  • Logo Sherpa/Romeo
    Check whether the anglo-saxon journal in which you have published an article allows you to also publish it under open access.
  • Logo Dulcinea
    Check whether the spanish journal in which you have published an article allows you to also publish it under open access.
  • Logo de Recolecta
  • Logo del Observatorio I+D+i UPM
  • Logo de OpenCourseWare UPM