A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes

Rodriguez Herrero, Agustin; Hernando Pérez, María Elena; Pérez Gandía, Carmen; Rigla Cros, Mercedes; Leiva, Alberto de y Gómez Aguilera, Enrique J. (2010). A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes. "Diabetes Technology AND Therapeutics", v. 12 (n. 2); pp. 95-104. ISSN 1520-9156. https://doi.org/10.1089/dia.2009.0093.

Descripción

Título: A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes
Autor/es:
  • Rodriguez Herrero, Agustin
  • Hernando Pérez, María Elena
  • Pérez Gandía, Carmen
  • Rigla Cros, Mercedes
  • Leiva, Alberto de
  • Gómez Aguilera, Enrique J.
Tipo de Documento: Artículo
Título de Revista/Publicación: Diabetes Technology AND Therapeutics
Fecha: Enero 2010
Volumen: 12
Materias:
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Tecnología Fotónica [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

Texto completo

[img]
Vista Previa
PDF (Document Portable Format) - Se necesita un visor de ficheros PDF, como GSview, Xpdf o Adobe Acrobat Reader
Descargar (516kB) | Vista Previa

Resumen

Background: Closed-loop control algorithms in diabetes aim to calculate the optimum insulin delivery to maintain the patient in a normoglycemic state, taking the blood glucose level as the algorithm's main input. The major difficulties facing these algorithms when applied subcutaneously are insulin absorption time and delays in measurement of subcutaneous glucose with respect to the blood concentration. Methods: This article presents an inverse controller (IC) obtained by inversion of an existing mathematical model and validated with synthetic patients simulated with a different model and is compared with a proportional-integral-derivative controller. Results: Simulated results are presented for a mean patient and for a population of six simulated patients. The IC performance is analyzed for both full closed-loop and semiclosed-loop control. The IC is tested when initialized with the heuristic optimal gain, and it is compared with the performance when the initial gain is deviated from the optimal one (±10%). Conclusions: The simulation results show the viability of using an IC for closed-loop diabetes control. The IC is able to achieve normoglycemia over long periods of time when the optimal gain is used (63% for the full closed-loop control, and it is increased to 96% for the semiclosed-loop control)

Más información

ID de Registro: 8587
Identificador DC: http://oa.upm.es/8587/
Identificador OAI: oai:oa.upm.es:8587
Identificador DOI: 10.1089/dia.2009.0093
URL Oficial: http://www.liebertonline.com/doi/abs/10.1089/dia.2009.0093
Depositado por: Memoria Investigacion
Depositado el: 10 Ago 2011 10:09
Ultima Modificación: 20 Abr 2016 17:19
  • Open Access
  • Open Access
  • Sherpa-Romeo
    Compruebe si la revista anglosajona en la que ha publicado un artículo permite también su publicación en abierto.
  • Dulcinea
    Compruebe si la revista española en la que ha publicado un artículo permite también su publicación en abierto.
  • Recolecta
  • e-ciencia
  • Observatorio I+D+i UPM
  • OpenCourseWare UPM