A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes

Rodriguez Herrero, Agustin and Hernando Pérez, María Elena and Pérez Gandía, Carmen and Rigla Cros, Mercedes and Leiva, Alberto de and Gómez Aguilera, Enrique J. (2010). A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes. "Diabetes Technology AND Therapeutics", v. 12 (n. 2); pp. 95-104. ISSN 1520-9156. https://doi.org/10.1089/dia.2009.0093.

Description

Title: A Simulation Study of an Inverse Controller for Closed and Semiclosed-Loop Control in Type 1 Diabetes
Author/s:
  • Rodriguez Herrero, Agustin
  • Hernando Pérez, María Elena
  • Pérez Gandía, Carmen
  • Rigla Cros, Mercedes
  • Leiva, Alberto de
  • Gómez Aguilera, Enrique J.
Item Type: Article
Título de Revista/Publicación: Diabetes Technology AND Therapeutics
Date: January 2010
ISSN: 1520-9156
Volume: 12
Subjects:
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Background: Closed-loop control algorithms in diabetes aim to calculate the optimum insulin delivery to maintain the patient in a normoglycemic state, taking the blood glucose level as the algorithm's main input. The major difficulties facing these algorithms when applied subcutaneously are insulin absorption time and delays in measurement of subcutaneous glucose with respect to the blood concentration. Methods: This article presents an inverse controller (IC) obtained by inversion of an existing mathematical model and validated with synthetic patients simulated with a different model and is compared with a proportional-integral-derivative controller. Results: Simulated results are presented for a mean patient and for a population of six simulated patients. The IC performance is analyzed for both full closed-loop and semiclosed-loop control. The IC is tested when initialized with the heuristic optimal gain, and it is compared with the performance when the initial gain is deviated from the optimal one (±10%). Conclusions: The simulation results show the viability of using an IC for closed-loop diabetes control. The IC is able to achieve normoglycemia over long periods of time when the optimal gain is used (63% for the full closed-loop control, and it is increased to 96% for the semiclosed-loop control)

More information

Item ID: 8587
DC Identifier: http://oa.upm.es/8587/
OAI Identifier: oai:oa.upm.es:8587
DOI: 10.1089/dia.2009.0093
Official URL: http://www.liebertonline.com/doi/abs/10.1089/dia.2009.0093
Deposited by: Memoria Investigacion
Deposited on: 10 Aug 2011 10:09
Last Modified: 20 Apr 2016 17:19
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