Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.

Perales Castellanos, Nazareth; Paúl, Nuria; Ordoñez, Victoria E.; Demuynck, Oliver; Bajo Breton, Ricardo; Campo, Pablo; Bilbao, Alvaro; Ortiz, Tomas; Pozo Guerrero, Francisco del y Maestú, Fernando (2010). Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.. "Brain: a Journal of Neurology", v. 133 (n. 8); pp. 2365-2381. ISSN 0006-8950. https://doi.org/10.1093/brain/awq174.

Descripción

Título: Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.
Autor/es:
  • Perales Castellanos, Nazareth
  • Paúl, Nuria
  • Ordoñez, Victoria E.
  • Demuynck, Oliver
  • Bajo Breton, Ricardo
  • Campo, Pablo
  • Bilbao, Alvaro
  • Ortiz, Tomas
  • Pozo Guerrero, Francisco del
  • Maestú, Fernando
Tipo de Documento: Artículo
Título de Revista/Publicación: Brain: a Journal of Neurology
Fecha: Agosto 2010
Volumen: 133
Materias:
Palabras Clave Informales: brain injury; functional connectivity; magnetoencephalography; plasticity
Escuela: E.T.S.I. Telecomunicación (UPM)
Departamento: Tecnología Fotónica [hasta 2014]
Licencias Creative Commons: Reconocimiento - Sin obra derivada - No comercial

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Resumen

Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on functional connectivity patterns. Networks were calculated from resting-state magnetoencephalographic recordings from 15 brain injured patients and 14 healthy controls by means of wavelet coherence in standard frequency bands. We compared the parameters defining the network, such as number and strength of interactions as well as their topology, in controls and patients for two conditions: following a traumatic brain injury and after a rehabilitation treatment. A loss of delta- and theta-based connectivity and conversely an increase in alpha- and beta-band-based connectivity were found. Furthermore, connectivity parameters approached controls in all frequency bands, especially in slow-wave bands. A correlation between network reorganization and cognitive recovery was found: the reduction of delta-band-based connections and the increment of those based on alpha band correlated with Verbal Fluency scores, as well as Perceptual Organization and Working Memory Indexes, respectively. Additionally, changes in connectivity values based on theta and beta bands correlated with the Patient Competency Rating Scale. The current study provides new evidence of the neurophysiological mechanisms underlying neuronal plasticity processes after brain injury, and suggests that these changes are related with observed changes at the behavioural level

Más información

ID de Registro: 8595
Identificador DC: http://oa.upm.es/8595/
Identificador OAI: oai:oa.upm.es:8595
Identificador DOI: 10.1093/brain/awq174
URL Oficial: http://brain.oxfordjournals.org/content/133/8/2365.abstract
Depositado por: Memoria Investigacion
Depositado el: 10 Ago 2011 07:53
Ultima Modificación: 04 Mar 2015 16:03
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