Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.

Perales Castellanos, Nazareth and Paúl, Nuria and Ordoñez, Victoria E. and Demuynck, Oliver and Bajo Breton, Ricardo and Campo, Pablo and Bilbao, Alvaro and Ortiz, Tomas and Pozo Guerrero, Francisco del and Maestú, Fernando (2010). Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.. "Brain: a Journal of Neurology", v. 133 (n. 8); pp. 2365-2381. ISSN 0006-8950. https://doi.org/10.1093/brain/awq174.

Description

Title: Reorganization of functional connectivity as a correlate of cognitive recovery in acquired brain injury.
Author/s:
  • Perales Castellanos, Nazareth
  • Paúl, Nuria
  • Ordoñez, Victoria E.
  • Demuynck, Oliver
  • Bajo Breton, Ricardo
  • Campo, Pablo
  • Bilbao, Alvaro
  • Ortiz, Tomas
  • Pozo Guerrero, Francisco del
  • Maestú, Fernando
Item Type: Article
Título de Revista/Publicación: Brain: a Journal of Neurology
Date: August 2010
ISSN: 0006-8950
Volume: 133
Subjects:
Freetext Keywords: brain injury; functional connectivity; magnetoencephalography; plasticity
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Cognitive processes require a functional interaction between specialized multiple, local and remote brain regions. Although these interactions can be strongly altered by an acquired brain injury, brain plasticity allows network reorganization to be principally responsible for recovery. The present work evaluates the impact of brain injury on functional connectivity patterns. Networks were calculated from resting-state magnetoencephalographic recordings from 15 brain injured patients and 14 healthy controls by means of wavelet coherence in standard frequency bands. We compared the parameters defining the network, such as number and strength of interactions as well as their topology, in controls and patients for two conditions: following a traumatic brain injury and after a rehabilitation treatment. A loss of delta- and theta-based connectivity and conversely an increase in alpha- and beta-band-based connectivity were found. Furthermore, connectivity parameters approached controls in all frequency bands, especially in slow-wave bands. A correlation between network reorganization and cognitive recovery was found: the reduction of delta-band-based connections and the increment of those based on alpha band correlated with Verbal Fluency scores, as well as Perceptual Organization and Working Memory Indexes, respectively. Additionally, changes in connectivity values based on theta and beta bands correlated with the Patient Competency Rating Scale. The current study provides new evidence of the neurophysiological mechanisms underlying neuronal plasticity processes after brain injury, and suggests that these changes are related with observed changes at the behavioural level

More information

Item ID: 8595
DC Identifier: http://oa.upm.es/8595/
OAI Identifier: oai:oa.upm.es:8595
DOI: 10.1093/brain/awq174
Official URL: http://brain.oxfordjournals.org/content/133/8/2365.abstract
Deposited by: Memoria Investigacion
Deposited on: 10 Aug 2011 07:53
Last Modified: 04 Mar 2015 16:03
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