Functional properties of the human ventral mesencephalic neural stem cell line hVM1.

Tonnesen, Jan and Gonzalez Seiz, Emma and Ramos Gomez, Milagros and Lindval, Olle and Martinez Serrano, Alberto and Kokaia, Merab (2010). Functional properties of the human ventral mesencephalic neural stem cell line hVM1.. "Experimental Neurology", v. 223 (n. 2); p. 653. ISSN 0014-4886. https://doi.org/10.1016/j.expneurol.2010.01.013.

Description

Title: Functional properties of the human ventral mesencephalic neural stem cell line hVM1.
Author/s:
  • Tonnesen, Jan
  • Gonzalez Seiz, Emma
  • Ramos Gomez, Milagros
  • Lindval, Olle
  • Martinez Serrano, Alberto
  • Kokaia, Merab
Item Type: Article
Título de Revista/Publicación: Experimental Neurology
Date: June 2010
Volume: 223
Subjects:
Freetext Keywords: Human neural stem cell; Dopaminergic neuron; In vitro; Electrophysiology; Functional properties; Differentiation; Parkinson's disease
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

The human fetal ventral mesencephalon-derived stem cell line, hVM1, yields high number of tyrosine hydroxylase-expressing presumed dopaminergic neurons upon in vitro differentiation. Here we report that cells generated from this line differentiate into a neuronal phenotype, express electrophysiological properties of functional neurons and respond to neurotransmitters in vitro. However, the electrophysiological properties are immature and the cells require longer maturation time than possible under in vitro conditions

Funding Projects

TypeCodeAcronymLeaderTitle
FP7214706EXCELLUnspecifiedExploring Cellular Dynamics at Nanoscale
FP7222943NEUROSTEMCELLUnspecifiedEuropean Consortium for Stem Cell Therapy for Neurodegenerative Diseases

More information

Item ID: 8596
DC Identifier: http://oa.upm.es/8596/
OAI Identifier: oai:oa.upm.es:8596
DOI: 10.1016/j.expneurol.2010.01.013
Official URL: http://www.sciencedirect.com/science/journal/00144886
Deposited by: Memoria Investigacion
Deposited on: 10 Aug 2011 07:24
Last Modified: 06 Jun 2018 10:29
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