Functional connectivity in mild cognitive impairment during a memory task: implications for the disconnection hypothesis.

Bajo Breton, Ricardo and Maestú, Fernando and Nevado, Angel and Sancho, Miguel and Gutierrez, Ricardo and Campo, Pablo and Perales Castellanos, Nazareth and Gil, Pedro and Moratti, Stephan and Pereda, Ernesto and Pozo Guerrero, Francisco del (2010). Functional connectivity in mild cognitive impairment during a memory task: implications for the disconnection hypothesis.. "Journal of Alzheimer's Disease", v. 22 (n. 1); pp. 183-193. ISSN 1387-2877. https://doi.org/10.3233/JAD-2010-100177.

Description

Title: Functional connectivity in mild cognitive impairment during a memory task: implications for the disconnection hypothesis.
Author/s:
  • Bajo Breton, Ricardo
  • Maestú, Fernando
  • Nevado, Angel
  • Sancho, Miguel
  • Gutierrez, Ricardo
  • Campo, Pablo
  • Perales Castellanos, Nazareth
  • Gil, Pedro
  • Moratti, Stephan
  • Pereda, Ernesto
  • Pozo Guerrero, Francisco del
Item Type: Article
Título de Revista/Publicación: Journal of Alzheimer's Disease
Date: August 2010
ISSN: 1387-2877
Volume: 22
Subjects:
Freetext Keywords: Disconnection syndrome, functional connectivity, magnetoencephalography, memory, mild cognitive impairment, synchronization likelihood
Faculty: E.T.S.I. Telecomunicación (UPM)
Department: Tecnología Fotónica [hasta 2014]
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Mild cognitive impairment (MCI) has been considered an intermediate state between healthy aging and dementia. The early damage in anatomical connectivity and progressive loss of synapses that characterize early Alzheimer's disease suggest that MCI could also be a disconnection syndrome. Here, we compare the degree of synchronization of brain signals recorded with magnetoencephalography from patients (22) with MCI with that of healthy controls (19) during a memory task. Synchronization Likelihood, an index based on the theory of nonlinear dynamical systems, was used to measure functional connectivity. During the memory task patients showed higher interhemispheric synchronization than healthy controls between left and right -anterior temporo-frontal regions (in all studied frequency bands) and in posterior regions in the γ band. On the other hand, the connectivity pattern from healthy controls indicated two clusters of higher synchronization, one among left temporal sensors and another one among central channels. Both of them were found in all frequency bands. In the γ band, controls showed higher Synchronization Likelihood values than MCI patients between central-posterior and frontal-posterior channels and a high synchronization in posterior regions. The inter-hemispheric increased synchronization values could reflect a compensatory mechanism for the lack of efficiency of the memory networks in MCI patients. Therefore, these connectivity profiles support only partially the idea of MCI as a disconnection syndrome, as patients showed increased long distance inter-hemispheric connections but a decrease in antero-posterior functional connectivity

More information

Item ID: 8597
DC Identifier: http://oa.upm.es/8597/
OAI Identifier: oai:oa.upm.es:8597
DOI: 10.3233/JAD-2010-100177
Official URL: http://iospress.metapress.com/content/j620t49807531361/
Deposited by: Memoria Investigacion
Deposited on: 09 Aug 2011 11:57
Last Modified: 04 Mar 2015 16:03
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