Wheat allergy in celiac children

Martín Muñoz, M. F. and Rivero, D. and Diaz Perales, Araceli and Polanco, I. and Quirce, Santiago (2015). Wheat allergy in celiac children. "Pediatric Allergy And Immunology", v. 27 (n. 1); pp. 92-106. ISSN 0905-6157. https://doi.org/10.1111/pai.12487.


Title: Wheat allergy in celiac children
  • Martín Muñoz, M. F.
  • Rivero, D.
  • Diaz Perales, Araceli
  • Polanco, I.
  • Quirce, Santiago
Item Type: Article
Título de Revista/Publicación: Pediatric Allergy And Immunology
Date: February 2015
ISSN: 0905-6157
Volume: 27
Faculty: E.T.S.I. Agrónomos (UPM) [antigua denominación]
Department: Biotecnología - Biología Vegetal
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Gluten is the main structural protein complex of wheat with equivalent toxic proteins found in other cereals (rye, barley, and oats) which are responsible for different immunologic responses with different clinical expressions of disease. The spectrum of gluten-related disorders has been classified according to pathogenic, clinical, and epidemiological differences in three main forms: (i) wheat allergy (WA), an IgE-mediated disease; (ii) autoimmune disease, including celiac disease (CD), dermatitis herpetiformis, and gluten ataxia; and (iii) possibly immune-mediated, gluten sensitivity [1]. WA is an immunologic Th2 response with typical manifestations which can vary from dermatological, respiratory, and/or intestinal to anaphylactic reactions. In contrast, CD is an autoimmune disorder, a gliadin-specific T-cell response which is enhanced by the action of intestinal tissue transglutaminase (tTG), with a wide clinical spectrum including symptomatic cases with either intestinal (e.g., chronic diarrhea, weight loss) or extraintestinal features (e.g., anemia, osteoporosis, neurologic disturbances) and silent forms that are occasionally discovered as a result of serological screening [1]. We studied wheat allergy in two children with early diagnosis of CD, who developed immediate allergic symptoms after eating small amounts of wheat flour.

More information

Item ID: 41256
DC Identifier: https://oa.upm.es/41256/
OAI Identifier: oai:oa.upm.es:41256
DOI: 10.1111/pai.12487
Official URL: http://onlinelibrary.wiley.com/doi/10.1111/pai.124...
Deposited by: Memoria Investigacion
Deposited on: 21 Jun 2016 17:12
Last Modified: 28 Feb 2017 23:30
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