Changes in anatomical and functional connectivity related to lower hippocampal volume

Pineda Pardo, José Ángel and Cristóbal Huerta, Alexandra and Manzanedo Sáenz, Eva and Pozo Guerrero, Francisco del and Álvarez Linera, Juan and Hernández Tamames, J.A. (2014). Changes in anatomical and functional connectivity related to lower hippocampal volume. In: "Joint ISMRM-ESMRMB Milano 2014", 09/05/2014 - 16/05/2014, Milan, Italia. p. 1.

Description

Title: Changes in anatomical and functional connectivity related to lower hippocampal volume
Author/s:
  • Pineda Pardo, José Ángel
  • Cristóbal Huerta, Alexandra
  • Manzanedo Sáenz, Eva
  • Pozo Guerrero, Francisco del
  • Álvarez Linera, Juan
  • Hernández Tamames, J.A.
Item Type: Presentation at Congress or Conference (Poster)
Event Title: Joint ISMRM-ESMRMB Milano 2014
Event Dates: 09/05/2014 - 16/05/2014
Event Location: Milan, Italia
Title of Book: International Society for Magnetic Resonance in Medicine
Date: May 2014
Subjects:
Faculty: Centro de Tecnología Biomédica (CTB) (UPM)
Department: Tecnología Fotónica y Bioingeniería
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Anatomical 3D T1 weighted images have been widely used to assess the volume of subcortical structures. It has been demonstrated that volume loss of hippocampi, entorhinal cortex and amygdala are early biomarkers for the diagnosis of cognitive impairments and AD1. In this work, we investigate AD biomarkers based on brain connectivity. SC-FC differences have been reported between controls and patients at risk for AD2. We will try to anticipate to MCI or AD diagnoses by differentiating in a sample of healthy subjects, i.e. with no cognitive impairment, other than related to ageing, using as criterion of separation the normalized hippocampal volume (NHV). The sample is formed by volunteers in the Valleca?s Initiative, a longitudinal study evaluating normal ageing in a cohort of more than 600 healthy elder people (70-85 years). The prevalence of AD in people older than 65 years is 13%3 suggesting that a certain number of those subjects will develop AD in the next years. The subjects with lower NHV are more prone to have AD than subjects with higher NHV. Thus they are more likely to manifest connectivity patterns that can be considered as AD biomarkers.

Funding Projects

TypeCodeAcronymLeaderTitle
Government of SpainTEC2012-39095-C03-01UnspecifiedUnspecifiedUnspecified

More information

Item ID: 38969
DC Identifier: http://oa.upm.es/38969/
OAI Identifier: oai:oa.upm.es:38969
Deposited by: Memoria Investigacion
Deposited on: 06 May 2017 10:11
Last Modified: 06 May 2017 10:11
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