MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study

Cupeiro Coto, Rocío and Benito Peinado, Pedro José and Maffulli, Nicola and Calderón Montero, Francisco Javier and Gonzalez Lamuño, Domigo (2010). MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study. "Journal of Science and Medicine in Sport", v. 13 (n. 5); pp. 526-530. ISSN 1440-2440. https://doi.org/10.1016/j.jsams.2009.07.004.

Description

Title: MCT1 genetic polymorphism influence in high intensity circuit training: A pilot study
Author/s:
  • Cupeiro Coto, Rocío
  • Benito Peinado, Pedro José
  • Maffulli, Nicola
  • Calderón Montero, Francisco Javier
  • Gonzalez Lamuño, Domigo
Item Type: Article
Título de Revista/Publicación: Journal of Science and Medicine in Sport
Date: September 2010
ISSN: 1440-2440
Volume: 13
Subjects:
Freetext Keywords: Monocarboxylate transporters; Lactate accumulation; Circuit weight training; A1470T polymorphism
Faculty: Facultad de Ciencias de la Actividad Física y del Deporte (INEF) (UPM)
Department: Salud y Rendimiento Humano
Creative Commons Licenses: Recognition - No derivative works - Non commercial

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Abstract

Monocarboxylate Transporter 1 (MCT1) mediates the transport of the main fraction of lactate across the sarcolemma. A common polymorphic MCT1 variant has been identified, but its role in high intensity exercise performance has not been defined. We investigated the influence of MCT1 A1470T polymorphism (rs1049434) on lactate accumulation after high intensity circuit training. Ten men aged 20–26 performed three controlled circuit training (CWT) sessions at 60%, 70%, and 80% of the 15 repetition maximum (15 RM), in non-consecutive days. CWT included three sets of a circuit of eight exercises, obtaining lactate measurements immediately after each set had been completed. Two independent variables were analysed: MTC1 genotypes according to the presence or absence of the A1470T polymorphism, and the intensity of circuit training. Genotype distributions were in Hardy–Weinberg equilibrium, being 30% wild-type, 50% heterozygotes, and 20% mutated homozygotes. Mean lactate concentration at 80% of 15 RM were significantly higher than the mean lactate values at the other intensities (p < 0.01). Significant differences between genetic groups were found in the lactate accumulation slope at 80% of 15 RM (p = 0.02) and in the maximal lactate concentration reached by all subjects in the study (Lmax) (p = 0.03). The carriers of the A1470T polymorphism in the MTC1 gene seem to exhibit a worse lactate transport capability into the less active muscle cells for oxidation.

More information

Item ID: 8622
DC Identifier: http://oa.upm.es/8622/
OAI Identifier: oai:oa.upm.es:8622
DOI: 10.1016/j.jsams.2009.07.004
Official URL: http://www.sciencedirect.com/science/journal/14402440
Deposited by: Memoria Investigacion
Deposited on: 08 Aug 2011 11:45
Last Modified: 20 Apr 2016 17:20
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